Zeilinger Katharina, Wessels Anna G, Vahjen Wilfried, Zentek Jürgen
Institute of Animal Nutrition, Department of Veterinary Medicine, Freie Universität Berlin, 14195 Berlin, Germany.
Transl Anim Sci. 2023 Mar 13;7(1):txad030. doi: 10.1093/tas/txad030. eCollection 2023 Jan.
Beneficial effects of pro- and prebiotics in weanling piglets are of great interest in livestock production. Similarly, the use of specific vaccines is of interest as alternative to antibiotics to reduce postweaning performance losses. The aim of this study was the assessment of the effect of a dual-strain probiotic ( and ) and a prebiotic (fructo-oligosaccharides) as well as the additional vaccination with an autogenous inactivated vaccine on the performance of newly weaned piglets after experimental infection with an enterotoxigenic Forty piglets at the age of 28 d were randomly allotted to one of five groups: nonchallenged control (NC); challenged positive control (PC); challenged and vaccinated (CV); challenged and diet supplemented with pre- and probiotic mix (CM) and challenged, diet supplemented with pro- and prebiotic mix and vaccinated (CMV). Piglets of CV and CMV were vaccinated parenterally prior to the trial at the age of 17 d. Compared to NC, the experimental infection with resulted in a significant reduction of body weight gain in both vaccinated groups ( = 0.045), which was associated with an impaired gain to feed ratio ( = 0.012), but not feed intake. In contrast, piglets in the group supplemented with pro- and prebiotics (group CM) were able to maintain their weight and had an average daily gain, which was not significantly different from groups NC and PC. No differences regarding body weight gain, feed intake, gain to feed ratio and fecal score were observed between groups during the 3rd and 4th week of the trial. A significant impairment of fecal consistency and frequency of diarrhea was observed related to the oral challenge when comparing PC and NC treatments ( = 0.024). Neither vaccine, nor supplementation with pro- and prebiotics were able to significantly improve fecal consistency, nor did they have a positive effect on the prevalence of diarrhea. The results show no positive synergistic effect of the specific combination of vaccine and pre- and probiotics used in this trial on performance and diarrhea. The results show that the concept of a combination of a specific vaccination and a probiotic with a prebiotic needs further investigation. In the sense of avoiding the use of antibiotics, this seems to be an attractive approach.
益生元和益生菌对断奶仔猪的有益作用在畜牧生产中备受关注。同样，使用特定疫苗作为抗生素的替代品以减少断奶后生产性能损失也受到关注。本研究的目的是评估双菌株益生菌（ 和 ）和益生元（低聚果糖），以及用自体灭活 疫苗进行额外接种对新断奶仔猪在实验感染产肠毒素 后的生产性能的影响。40头28日龄仔猪被随机分配到五组之一：未受挑战的对照组（NC）；受挑战的阳性对照组（PC）；受挑战且接种疫苗组（CV）；受挑战且日粮添加益生元和益生菌混合物组（CM）；受挑战、日粮添加益生元和益生菌混合物且接种疫苗组（CMV）。CV组和CMV组的仔猪在试验前17日龄时进行了肌肉注射接种。与NC组相比，实验感染 导致两个接种疫苗组的体重增加显著降低（ = 0.045），这与增重耗料比受损有关（ = 0.012），但采食量不受影响。相比之下，添加益生元和益生菌的组（CM组）仔猪能够维持体重，其平均日增重与NC组和PC组无显著差异。在试验的第3周和第4周期间，各处理组之间在体重增加、采食量、增重耗料比和粪便评分方面未观察到差异。比较PC组和NC组处理时，观察到与口服攻毒相关的粪便稠度和腹泻频率显著受损（ = 0.024）。疫苗接种和添加益生元和益生菌均不能显著改善粪便稠度，对腹泻发生率也没有积极影响。结果表明，本试验中使用的疫苗与益生元和益生菌的特定组合对生产性能和腹泻没有积极的协同作用。结果表明，特定疫苗接种与益生菌和益生元组合的概念需要进一步研究。从避免使用抗生素的角度来看，这似乎是一种有吸引力的方法。
