Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
Food Funct. 2023 May 11;14(9):3982-3993. doi: 10.1039/d2fo02567a.
Ulcerative colitis is an inflammatory bowel disease that is mainly related to gut microbiota dysbiosis. ZJ316 (ZJ316) has been proved to regulate the gut microbiota . However, more evidence is needed for the intestinal effects of ZJ316 . Colitis was induced dissolved 2.5% DSS in drinking water for 7 days in 8-week-old BALB/c mice, which were then fed with ZJ316 (1 × 10 CFU mL) for 35 days. After ZJ316 intervention, the dextran sulfate sodium salt (DSS)-induced colitis symptoms were remarkably alleviated, including recovery of body weight and colon weight and effective inhibition of the expression of pro-inflammatory cytokines. Results based on 16S rRNA gene sequencing indicated that the structure of the gut microbiota in ZJ316 supplementation was markedly altered by upregulating the percentage of while reducing the percentage of . Furthermore, the colon contained more short-chain fatty acids (SCFAs) and butyrate-producing genera, such as , , and . Spearman correlation analysis indicated that SCFAs, especially butyric acid, were positively associated with and Our study suggested that ZJ316 could be used to relieve ulcerative colitis (UC) as dietary therapeutics.
溃疡性结肠炎是一种炎症性肠病，主要与肠道微生物失调有关。ZJ316（ZJ316）已被证明可调节肠道微生物群。然而，还需要更多的证据来证明 ZJ316 的肠道作用。在 8 周龄 BALB/c 小鼠的饮用水中溶解 2.5% DSS 7 天，诱导结肠炎。然后，用 ZJ316（1×10 CFU mL）喂养 35 天。ZJ316 干预后，葡聚糖硫酸钠（DSS）诱导的结肠炎症状明显缓解，包括体重和结肠重量的恢复，以及促炎细胞因子表达的有效抑制。基于 16S rRNA 基因测序的结果表明，通过上调的百分比，ZJ316 补充显著改变了肠道微生物群的结构，同时降低了的百分比。此外，结肠含有更多的短链脂肪酸（SCFAs）和产生丁酸盐的属，如、和。Spearman 相关分析表明，SCFAs，特别是丁酸，与和呈正相关。我们的研究表明，ZJ316 可用作缓解溃疡性结肠炎（UC）的膳食治疗剂。
