College of Pharmacy, Weifang Medical University, Weifang, Shandong, PR China.
Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, PR China.
Crit Rev Food Sci Nutr. 2024;64(22):7707-7727. doi: 10.1080/10408398.2023.2191135. Epub 2023 Mar 27.
Seaweed polysaccharides (SPs) obtained from seaweeds are a class of functional prebiotics. SPs can regulate glucose and lipid anomalies, affect appetite, reduce inflammation and oxidative stress, and therefore have great potential for managing metabolic syndrome (MetS). SPs are poorly digested by the human gastrointestinal tract but are available to the gut microbiota to produce metabolites and exert a series of positive effects, which may be the mechanism by which SPs render their anti-MetS effects. This article reviews the potential of SPs as prebiotics in the management of MetS-related metabolic disturbances. The structure of SPs and studies related to the process of their degradation by gut bacteria and their therapeutic effects on MetS are highlighted. In summary, this review provides new perspectives on SPs as prebiotics to prevent and treat MetS.
海藻多糖（SPs）是从海藻中提取的一类功能性益生元。SPs 可以调节葡萄糖和脂质异常，影响食欲，减轻炎症和氧化应激，因此在治疗代谢综合征（MetS）方面具有很大的潜力。SPs 很难被人体胃肠道消化，但可以被肠道微生物群利用来产生代谢物，并发挥一系列积极作用，这可能是 SPs 发挥其抗 MetS 作用的机制。本文综述了 SPs 作为益生元在管理 MetS 相关代谢紊乱方面的潜力。本文强调了 SPs 的结构以及与肠道细菌降解其过程相关的研究，以及 SPs 对 MetS 的治疗效果。总之，本综述为 SPs 作为益生元预防和治疗 MetS 提供了新的视角。
