Key Laboratory of Marine Drugs of Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266003, China.
Obstetrics Department (Work Number 002312), Qingdao Municipal Hospital (Group), Qingdao, 266000, China.
Carbohydr Polym. 2018 Sep 1;195:601-612. doi: 10.1016/j.carbpol.2018.05.003. Epub 2018 May 2.
Marine polysaccharides (MPs), including plant, animal, and microbial-derived polysaccharides, can alleviate metabolic syndrome (MetS) by different regulation mechanisms. MPs and their derivatives can attenuate MetS by vary cellular signal pathways, such as peroxisome proliferator-activated receptor, 5' adenosine monophosphate-activated protein kinase, and CCAAT/enhancer binding protein-α. Also, most of MPs cannot be degraded by human innate enzymes, but they can be degraded and fermented by human gut microbiota. The final metabolic products of these polysaccharides are usually short-chain fatty acids (SCFAs), which can change the gut microbiota ecology by altering the existing percentage of special microorganisms. In addition, the SCFAs and changed gut microbiota can regulate enteroendocrine hormone secretion, blood glucose, lipid metabolism levels, and other MetS symptoms. Here, we summarize the up-to-date findings on the effects of MPs, particularly marine microbial-derived polysaccharides, and their metabolites on attenuating MetS.
海洋多糖（MPs）包括植物、动物和微生物来源的多糖，可通过不同的调节机制缓解代谢综合征（MetS）。MPs 及其衍生物可通过多种细胞信号通路（如过氧化物酶体增殖物激活受体、5' 腺苷单磷酸激活蛋白激酶和 CCAAT/增强子结合蛋白-α）来减轻 MetS。此外，大多数 MPs 不能被人体先天酶降解，但可被人体肠道微生物群降解和发酵。这些多糖的最终代谢产物通常为短链脂肪酸（SCFAs），可通过改变特定微生物的现有比例来改变肠道微生物群的生态。此外，SCFAs 和改变的肠道微生物群可调节肠内分泌激素分泌、血糖、血脂代谢水平和其他 MetS 症状。在这里，我们总结了关于 MPs，特别是海洋微生物来源的多糖及其代谢物对减轻 MetS 的最新研究结果。
