一种合成胸苷环3',5'-磷酸衍生物非对映异构体的简单方法。

A simple procedure for synthesis of diastereoisomers of thymidine cyclic 3',5'-phosphate derivatives.

作者信息

Lesnikowski Z J, Jaworska M, Stec W J

机构信息

Polish Academy of Sciences, Department of Bio-organic Chemistry, Lodz.

出版信息

Nucleic Acids Symp Ser. 1987(18):273-6.

Abstract

Diastereoisomeric thymidine cyclic (3',5')-methanephosphonates (3a), cyclic (3',5')-phosphoranilidates (3b) and cyclic (3',5')-phosphoranilidothioates (3c) were prepared by treatment of diastereoisomerically pure thymidine 3'-O-[O-(4-nitrophenyl)methanephosphonates] (2a), 3'-O-[O-(4-nitrophenyl)phosphoranilidates] (2b) or 3'-O-[O-(4-nitrophenyl)phosphoranilidothioates] (2c), respectively, with sodium hydroxide in dioxane-water solution.

摘要

通过分别用氢氧化钠的二氧六环 - 水溶液处理非对映体纯的胸苷3'-O-O-(4-硝基苯基)甲烷膦酸酯、3'-O-O-(4-硝基苯基)磷酰亚胺酯或3'-O-O-(4-硝基苯基)磷酰亚胺硫代酯，制备了非对映体异构的胸苷环状(3',5')-甲烷膦酸酯(3a)、环状(3',5')-磷酰亚胺酯(3b)和环状(3',5')-磷酰亚胺硫代酯(3c)。

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