三磷酸胸苷生物电子等排体的设计与合成。
Design and synthesis of bio-isosteres of thymidine triphosphate.
作者信息
Goldring A O, Balzarini J, Gilbert I H
机构信息
Welsh School of Pharmacy, University of Wales Cardiff, U.K.
出版信息
Bioorg Med Chem Lett. 1998 May 19;8(10):1211-4. doi: 10.1016/s0960-894x(98)00189-9.
PMID:9871737
Abstract
This paper describes the design and synthesis of potential isosteres of triphosphates which should show enhanced metabolic stability and lipophilicity compared to triphosphates. The triphosphate isosteres were then linked to nucleosides and evaluated for their inhibitory activity against HIV infection.
摘要
本文描述了三磷酸酯潜在生物电子等排体的设计与合成，与三磷酸酯相比，这些生物电子等排体应具有更高的代谢稳定性和亲脂性。然后将三磷酸酯生物电子等排体与核苷相连，并评估其对HIV感染的抑制活性。
Zotero 插件