5'-O-(4,4'-二甲氧基三甲基苯基)二胸苷基-(3,5')-4,4'-二甲氧基三苯甲基膦酸酯非对映异构体的合成与分离
Synthesis and separation of diastereoisomers of 5'-O-(4,4'-dimethoxytrimethylphenyl)dithymidyl-(3,5')-4,4' -dimethoxytriphenylmethanephosphonate.
作者信息
Wilk A, Stec W J
机构信息
Department of Bio-organic Chemistry, Polish Academy of Sciences, Lodz.
出版信息
Nucleic Acids Symp Ser. 1987(18):289-92.
PMID:3697144
Abstract
"In solution" synthesis and separation of diastereoisomers of 5'-O-(4,4'-dimethoxytriphenylmethyl)dithymidyl (3',5') 4,4'-dimethoxytriphenylmethanephosphonate (DMTTDMTT) is described. One of diastereoisomers was successfully crystallized and characterized by means of HPLC.
摘要
描述了5'-O-(4,4'-二甲氧基三苯甲基)二胸腺嘧啶核苷(3',5') 4,4'-二甲氧基三苯甲基膦酸酯(DMTTDMTT)非对映异构体的“溶液中”合成与分离。其中一种非对映异构体成功结晶，并通过高效液相色谱法进行了表征。
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