Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
IUBMB Life. 2023 Apr;75(4):337-352. doi: 10.1002/iub.2716.
In October 2020, we were finally able to gather for a celebration of Eddy Fischer's 100th birthday. As with many other events, COVID had disrupted and restricted preparations for the gathering, which ultimately was held via ZOOM. Nevertheless, it was a wonderful opportunity to share a day with Eddy, an exceptional scientist and true renaissance man, and to appreciate his stellar contributions to science. Eddy Fischer, together with Ed Krebs, was responsible for the discovery of reversible protein phosphorylation, which launched the entire field of signal transduction. The importance of this seminal work is now being felt throughout the biotechnology industry with the development of drugs that target protein kinases, which have transformed the treatment of a wide array of cancers. I was privileged to have worked with Eddy both as a postdoc and a junior faculty member, during which time we laid the foundations for our current understanding of the protein tyrosine phosphatase (PTP) family of enzymes and their importance as critical regulators of signal transduction. This tribute to Eddy is based upon the talk I presented at the event, giving a personal perspective on Eddy's influence on my career, our early research efforts together in this area, and how the field has developed since then.
2020 年 10 月，我们终于能够齐聚一堂，庆祝埃迪·费舍尔（Eddy Fischer）的 100 岁生日。与许多其他活动一样，新冠疫情打乱并限制了聚会的筹备工作，最终聚会是通过 ZOOM 举行的。然而，这是与埃迪共度一天的绝佳机会，他是一位杰出的科学家，真正的文艺复兴人，值得我们欣赏他在科学领域的杰出贡献。埃迪·费舍尔（Eddy Fischer）与埃德·克莱布斯（Ed Krebs）一起发现了蛋白质可逆磷酸化，这开创了信号转导的整个领域。这项开创性工作的重要性现在正在整个生物技术行业中感受到，因为针对蛋白激酶的药物的开发已经改变了广泛癌症的治疗方法。我有幸在博士后和初级教员期间与埃迪一起工作，在此期间，我们为我们目前对蛋白酪氨酸磷酸酶（PTP）酶家族及其作为信号转导关键调节剂的重要性的理解奠定了基础。这篇献给埃迪的文章是基于我在活动中发表的演讲，从个人角度介绍了埃迪对我职业生涯的影响、我们在该领域的早期合作以及该领域此后的发展情况。
