Laboratoire Chimie Bactérienne, LCB-UMR 7283, Institut Microbiologie Méditerranée, CNRS/Université Aix-Marseille, Marseille, France.
Microbiology (Reading). 2023 Mar;169(3). doi: 10.1099/mic.0.001312.
Toxic agents added into the medium of rapidly growing induce specific stress responses through the activation of specialized transcription factors. Each transcription factor and downstream regulon (e.g. SoxR) are linked to a unique stress (e.g. superoxide stress). Cells starved of phosphate induce several specific stress regulons during the transition to stationary phase when the growth rate is steadily declining. Whereas the regulatory cascades leading to the expression of specific stress regulons are well known in rapidly growing cells stressed by toxic products, they are poorly understood in cells starved of phosphate. The intent of this review is to both describe the unique mechanisms of activation of specialized transcription factors and discuss signalling cascades leading to the induction of specific stress regulons in phosphate-starved cells. Finally, I discuss unique defence mechanisms that could be induced in cells starved of ammonium and glucose.
有毒物质被添加到快速生长的培养基中，通过激活专门的转录因子诱导特定的应激反应。每个转录因子和下游调节基因（如 SoxR）都与一种独特的应激（如超氧化物应激）相关联。在生长速率稳定下降的进入静止期的转变过程中，磷酸盐饥饿的细胞会诱导几个特定的应激调节基因。虽然在受到有毒产物胁迫的快速生长细胞中，导致特定应激调节基因表达的调节级联反应是众所周知的，但在磷酸盐饥饿的细胞中，这些反应机制了解甚少。这篇综述的目的是描述专门的转录因子的激活的独特机制，并讨论导致磷酸盐饥饿细胞中特定应激调节基因诱导的信号级联反应。最后，我将讨论在饥饿的铵和葡萄糖的细胞中可能诱导的独特防御机制。
