University of Minnesota Medical School, Minneapolis, MN, USA.
Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.
J Perinatol. 2023 Jun;43(6):702-708. doi: 10.1038/s41372-023-01649-w. Epub 2023 Mar 27.
Identify clinical factors that delay or prolong spontaneous regression of retinopathy of prematurity (ROP).
Secondary analysis of three prospective studies with 76 infants with ROP not requiring treatment, born ≤30 weeks postmenstrual age (PMA) and ≤1500 grams. Outcomes were PMA at greatest severity of ROP (PMA MSROP), at which regression began, at time of complete vascularization (PMA CV), and regression duration. Pearson's correlation coefficients, t-tests, or analyses of variance were calculated.
Increased positive bacterial cultures, hyperglycemia, transfusion volume of platelets and red blood cells and severity of ROP were associated with later PMA MSROP. Positive bacterial cultures, maternal chorioamnionitis, and less iron deficiency were associated with later PMA CV and prolonged regression duration. Slower length gain was associated with later PMA CV. P < 0.05 for all.
Preterm infants with inflammatory exposures or linear growth impairment may require longer surveillance for ROP resolution and complete vascularization.
确定延迟或延长早产儿视网膜病变（ROP）自发消退的临床因素。
对三项前瞻性研究的二次分析，纳入 76 名未接受治疗的≤30 孕周出生且≤1500 克的 ROP 婴儿。结局为 ROP 最严重时的矫正胎龄（矫正胎龄至 ROP 最严重时，即 PMA MSROP）、开始消退的时间、完全血管化时的矫正胎龄（矫正胎龄至完全血管化，即 PMA CV）和消退持续时间。计算 Pearson 相关系数、t 检验或方差分析。
阳性细菌培养、高血糖、血小板和红细胞输注量以及 ROP 严重程度与较晚的 PMA MSROP 相关。阳性细菌培养、绒毛膜羊膜炎和较少的缺铁与较晚的 PMA CV 和较长的消退持续时间相关。生长速度较慢与较晚的 PMA CV 相关。所有结果均 P<0.05。
有炎症暴露或线性生长受损的早产儿可能需要更长时间的 ROP 消退和完全血管化监测。
