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TEDC2 与肺腺癌的预后和免疫微环境相关。

TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma.

机构信息

Department of Thoracic Surgery, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

出版信息

Sci Rep. 2023 Mar 27;13(1):5006. doi: 10.1038/s41598-023-32238-8.

DOI:10.1038/s41598-023-32238-8
PMID:36973475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10042817/
Abstract

Tubulin epsilon and delta complex 2 (TEDC2) is a protein coding gene whose functions are poorly identified yet. This study aimed to identify the role of TEDC2 in prognosis and immune microenvironment of lung adenocarcinoma (LUAD). Through The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, the mRNA expression of TEDC2 was upregulated in LUAD tissues compared to normal tissues. The protein level of TEDC2 was also higher in LUAD in the Human Protein Atlas. The receiver operating characteristic (ROC) curve showed that high TEDC2 level could distinguish LUAD patients from normal subjects. In addition, the impact of TEDC2 expression on prognosis was evaluated by Kaplan-Meier and Cox regression analyses, and the results suggested that high TEDC2 expression was significantly associated with poor prognosis and was the independent prognostic factor in LUAD. GO and KEGG pathway analyses indicated the co-expressed genes of TEDC2 were mainly related to mitotic cell cycle processes. Importantly, high expression of TEDC2 indicated low infiltration of immune cells, especially dendritic cells and B cells. TEDC2 was also positively correlated with immune checkpoints such as PDCD1, LAG3 and CD276. Taken together, this study preliminarily revealed the clinical significance of TEDC2 in LUAD and provided novel insights into the role of TEDC2 in immune microenvironment.

摘要

微管蛋白 ε 和 δ 复合物 2（TEDC2）是一个蛋白编码基因，其功能尚未明确。本研究旨在探讨 TEDC2 在肺腺癌（LUAD）中的预后及免疫微环境中的作用。通过癌症基因组图谱（TCGA）和基因表达综合数据库（GEO），与正常组织相比，LUAD 组织中 TEDC2 的 mRNA 表达上调。在人类蛋白质图谱中，TEDC2 的蛋白水平在 LUAD 中也更高。受试者工作特征（ROC）曲线表明，高 TEDC2 水平可将 LUAD 患者与正常个体区分开来。此外，通过 Kaplan-Meier 和 Cox 回归分析评估 TEDC2 表达对预后的影响，结果表明，高 TEDC2 表达与不良预后显著相关，是 LUAD 的独立预后因素。GO 和 KEGG 通路分析表明，TEDC2 的共表达基因主要与有丝分裂细胞周期过程相关。重要的是，TEDC2 高表达表明免疫细胞浸润水平较低，尤其是树突状细胞和 B 细胞。TEDC2 还与免疫检查点如 PDCD1、LAG3 和 CD276 呈正相关。综上所述，本研究初步揭示了 TEDC2 在 LUAD 中的临床意义，并为 TEDC2 在免疫微环境中的作用提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/69f5612bd4c0/41598_2023_32238_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/69f5612bd4c0/41598_2023_32238_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/333e9a463840/41598_2023_32238_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/3d9c96bbea81/41598_2023_32238_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/077cc84cfafc/41598_2023_32238_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/78e1d82b2242/41598_2023_32238_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/14500b4352fa/41598_2023_32238_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/9a69c42c4774/41598_2023_32238_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/0c7f42c4edd7/41598_2023_32238_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/cad6e48c533c/41598_2023_32238_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/4b5960c275bf/41598_2023_32238_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/b19040693f0e/41598_2023_32238_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2ba/10042817/69f5612bd4c0/41598_2023_32238_Fig11_HTML.jpg

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