Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Skin Res Technol. 2023 Mar;29(3):e13285. doi: 10.1111/srt.13285.
Dermatosis is a general term for diseases of the skin and skin appendages including scleroderma, psoriasis, bullous disease, atopic dermatitis, basal cell carcinoma, squamous cell carcinoma, and melanoma. These diseases affect millions of individuals globally and are a serious public health concern. However, the pathogenesis of skin diseases is not fully understood, and treatments are not optimal. Yes-associated protein (YAP) is a transcriptional coactivator that plays a role in the regulation of gene transcription and signal transduction.
To study the role of Yes-associated protein in skin diseases.
The present review summarizes recent advances in our understanding of the role of YAP in skin diseases, current treatments that target YAP, and potential avenues for novel therapies.
Abnormal YAP expression has been implicated in occurrence and development of dermatosis. YAP regulates the cell homeostasis, proliferation, differentiation, apoptosis, angiopoiesis, and epithelial-to-mesenchymal transition, among other processes. As well as, it serves as a potential target in many biological processes for treating dermatosis.
The effects of YAP on the skin are complex and require multidimensional investigational approaches. YAP functions as an oncoprotein that can promote the occurrence and development of cancer, but there is currently limited information on the therapeutic potential of YAP inhibition for cancer treatment. Additional studies are also needed to clarify the role of YAP in the development and maturation of dermal fibroblasts; skin barrier function, homeostasis, aging, and melanin production; and dermatosis.
皮肤病是皮肤和皮肤附属器疾病的统称，包括硬皮病、银屑病、大疱性疾病、特应性皮炎、基底细胞癌、鳞状细胞癌和黑色素瘤。这些疾病影响着全球数百万人，是一个严重的公共卫生问题。然而，皮肤疾病的发病机制尚未完全阐明，治疗方法也不是最佳的。Yes 相关蛋白（YAP）是一种转录共激活因子，在基因转录和信号转导的调节中发挥作用。
研究 Yes 相关蛋白在皮肤病中的作用。
本综述总结了近年来我们对 YAP 在皮肤病中的作用、目前针对 YAP 的治疗方法以及潜在的新疗法途径的理解进展。
异常的 YAP 表达与皮肤病的发生和发展有关。YAP 调节细胞内稳态、增殖、分化、凋亡、血管生成和上皮间质转化等过程。此外，它还作为许多生物过程中治疗皮肤病的潜在靶点。
YAP 对皮肤的影响是复杂的，需要多维的研究方法。YAP 作为一种癌蛋白，可促进癌症的发生和发展，但目前关于 YAP 抑制治疗癌症的治疗潜力的信息有限。还需要进一步的研究来阐明 YAP 在真皮成纤维细胞的发育和成熟、皮肤屏障功能、内稳态、衰老和黑色素生成以及皮肤病中的作用。
