Jia Jinjing, Wang Yuqian, Mo Xiumei, Chen Dacan
State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
Department of Dermatology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
J Pers Med. 2022 Jun 16;12(6):978. doi: 10.3390/jpm12060978.
Psoriasis and skin tumors (such as basal cell carcinoma, squamous cell carcinoma, and melanoma) are chronic diseases that endanger physical and mental health, and yet the causes are largely unknown and treatment options limited. The development of targeted drugs requires a better understanding of the exact pathogenesis of these diseases, and Yes-associated protein (YAP), a member of the Hippo signaling pathway, is believed to play an important role. Psoriasis and skin tumors are characterized by excessive cell proliferation, abnormal differentiation, vasodilation, and proliferation. Here, we review the literature related to YAP-associated disease mechanisms and discuss the latest research. YAP regulates cell apoptosis, proliferation, and differentiation; inhibits cell density and intercellular contacts and angiogenesis; and maintains the three-dimensional structure of the skin. These mechanisms may be associated with the occurrence and development of psoriasis and skin tumors. The results of recent studies have shown that YAP expression is increased in psoriasis and skin tumors. High expression of YAP in psoriasis and skin tumors may indicate its positive functions in skin inflammation and malignancies and may play an important role in disease pathogenesis. The study of new drugs targeting YAP can provide novel approaches for the treatment of skin diseases.
银屑病和皮肤肿瘤（如基底细胞癌、鳞状细胞癌和黑色素瘤）是危害身心健康的慢性疾病，但其病因大多不明，治疗选择有限。靶向药物的研发需要更好地了解这些疾病的确切发病机制，而Yes相关蛋白（YAP）作为Hippo信号通路的一员，被认为发挥着重要作用。银屑病和皮肤肿瘤的特征是细胞过度增殖、分化异常、血管舒张和增生。在此，我们综述了与YAP相关疾病机制的文献，并讨论了最新研究。YAP调节细胞凋亡、增殖和分化；抑制细胞密度、细胞间接触和血管生成；并维持皮肤的三维结构。这些机制可能与银屑病和皮肤肿瘤的发生发展有关。最近的研究结果表明，YAP在银屑病和皮肤肿瘤中表达增加。YAP在银屑病和皮肤肿瘤中的高表达可能表明其在皮肤炎症和恶性肿瘤中的积极作用，并且可能在疾病发病机制中发挥重要作用。针对YAP的新药研究可为皮肤病治疗提供新方法。
