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FOXP3 高密度预示生发中心和非生发中心弥漫性大 B 细胞淋巴瘤具有更好的预后。

High density of FOXP3 predicts better prognosis in germinal and non-germinal centre diffuse large B-cell lymphoma.

机构信息

Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Department of Oncologic Pathology, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt.

出版信息

Int J Exp Pathol. 2023 Jun;104(3):128-139. doi: 10.1111/iep.12477. Epub 2023 Mar 28.

DOI:10.1111/iep.12477
PMID:36974470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10182367/
Abstract

This study highlights the prognostic impact of FOXP3 and CD68 expression in DLBCL, NOS and in its GCB and non-GCB subtypes. This may help the development of individualized therapy, prognostic prediction and therapy stratification.

摘要

本研究强调了 FOXP3 和 CD68 表达在弥漫性大 B 细胞淋巴瘤、NOS 及其 GCB 和非 GCB 亚型中的预后影响。这可能有助于个体化治疗、预后预测和治疗分层的发展。

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本文引用的文献

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Risk Stratification for Diffuse Large B-Cell Lymphoma by Integrating Interim Evaluation and International Prognostic Index: A Multicenter Retrospective Study.通过整合中期评估和国际预后指数对弥漫性大B细胞淋巴瘤进行风险分层：一项多中心回顾性研究
Front Oncol. 2021 Dec 16;11:754964. doi: 10.3389/fonc.2021.754964. eCollection 2021.
2
The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study.FoxP3+ 调节性 T 细胞和 IDO+ 免疫和肿瘤细胞在恶性黑色素瘤中的作用——免疫组化研究。
BMC Cancer. 2021 May 29;21(1):641. doi: 10.1186/s12885-021-08385-4.
3
Tumor-Associated Macrophages in Tumor Immunity.肿瘤相关巨噬细胞在肿瘤免疫中的作用。
Front Immunol. 2020 Dec 3;11:583084. doi: 10.3389/fimmu.2020.583084. eCollection 2020.
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Prognostic role of regulatory T cells in lymphoma: a systematic review and meta-analysis.调节性T细胞在淋巴瘤中的预后作用：一项系统评价和荟萃分析。
J Cancer Res Clin Oncol. 2020 Dec;146(12):3123-3135. doi: 10.1007/s00432-020-03398-1. Epub 2020 Sep 29.
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Inflammatory Cells in Diffuse Large B Cell Lymphoma.弥漫性大B细胞淋巴瘤中的炎症细胞
J Clin Med. 2020 Jul 28;9(8):2418. doi: 10.3390/jcm9082418.
6
Aberrant peripheral blood CD4 CD25 FOXP3 regulatory T cells/T helper-17 number is associated with the outcome of patients with lymphoma.异常外周血 CD4 CD25 FOXP3 调节性 T 细胞/T 辅助-17 细胞数量与淋巴瘤患者的预后相关。
Cancer Immunol Immunother. 2020 Sep;69(9):1917-1928. doi: 10.1007/s00262-020-02591-y. Epub 2020 May 8.
7
Classifying DLBCL according cell of origin using Hans algorithm and its association with clinicopathological parameters: A single centre experience.根据 Hans 算法对生发中心细胞起源进行 DLBCL 分类及其与临床病理参数的关系：单中心经验。
Med J Malaysia. 2020 Mar;75(2):98-102.
8
Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis.弥漫性大 B 细胞淋巴瘤中的肿瘤微环境：作用与预后。
Anal Cell Pathol (Amst). 2019 Dec 16;2019:8586354. doi: 10.1155/2019/8586354. eCollection 2019.
9
Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity.代谢调控 Treg 细胞稳定性、可塑性和组织特异性异质性。
Front Immunol. 2019 Dec 11;10:2716. doi: 10.3389/fimmu.2019.02716. eCollection 2019.
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BMC Cancer. 2019 Nov 6;19(1):1049. doi: 10.1186/s12885-019-6208-x.