Department of Gynecology and Obstetrics, Santa Casa of São Paulo Medical School, São Paulo, Brazil.
Asian Pac J Cancer Prev. 2023 Mar 1;24(3):867-872. doi: 10.31557/APJCP.2023.24.3.867.
The objective was to determine the prevalence of abnormal cytologic smears in a large population of a Brazilian city.
Retrospective study of cervical cytology results performed at a private laboratory in São Paulo - Brazil. A total of 1,030,482 cytology tests were performed between January 2010 and December 2015.
Among the satisfactory cytologies, we observed abnormal results in 8.9% (91,371). Analyzing the proportion of exams with altered results over the years, there was no change in these rates. We observed that the proportion of abnormal exams decreased with increasing age. Atypical squamous cells of undetermined significance, possibly non-neoplastic (ASC-US) cytology was the most common abnormality found in the general population with 73.19%, followed by low-grade intraepithelial lesion (LSIL) with 20.5%; these 2 cytological abnormalities add up to 93.69 % of all abnormal results. There was an increase in ASC-US with advancing age, a decrease in prevalence of LSIL, especially after the age of 30 and high-grade intraepithelial lesion (HSIL) shows two peaks of elevation, respectively in the age groups of 30-39 years and over 70 years.
Women under the age of 30 showed a higher prevalence of cytological abnormalities, however most of these changes are low-grade lesions. In older women, cytological abnormalities are largely high-grade lesions, requiring greater care to prevent progression to cancer.
目的是确定巴西某大城市大量人群中异常细胞学涂片的流行率。
对巴西圣保罗一家私人实验室的宫颈细胞学结果进行回顾性研究。2010 年 1 月至 2015 年 12 月共进行了 1030482 例细胞学检查。
在满意的细胞学中，我们观察到 8.9%（91371 例）有异常结果。分析多年来改变结果的检查比例，这些比率没有变化。我们发现异常检查的比例随年龄增长而降低。非典型鳞状细胞意义不明确，可能非肿瘤性（ASC-US）细胞学是普通人群中最常见的异常，占 73.19%，其次是低级别上皮内病变（LSIL）占 20.5%；这两种细胞学异常占所有异常结果的 93.69%。ASC-US 随年龄增长而增加，LSIL 的患病率下降，尤其是 30 岁以后，高级别上皮内病变（HSIL）显示出两个升高峰值，分别在 30-39 岁和 70 岁以上年龄组。
30 岁以下的女性细胞学异常发生率较高，但大多数为低级别病变。在老年女性中，细胞学异常主要为高级别病变，需要更密切的关注以防止进展为癌症。
