Dontsov V I
Biull Eksp Biol Med. 1986 Apr;101(4):479-80.
Isoproterenol-induced hyperplastic reaction has demonstrated decreased proliferative potency of salivary gland tissue in adult mice. Activation of serotoninergic mechanisms of lymphoid regulation by serotonin administration also decreased salivary gland hyperplastic reaction, predominantly in young mice. Dopamine administration enhanced the reaction in adult mice, it reaching the level observed in young animals. The number of spleen activated low density lymphocytes decreased in the case of serotonin-induced inhibition of hyperplastic reaction to isoproterenol and increased in the case of reaction stimulation. These lymphocytes have been previously shown to regulate salivary gland tissue proliferation in response to isoproterenol.
异丙肾上腺素诱导的增生反应已表明成年小鼠唾液腺组织的增殖能力下降。通过给予血清素激活淋巴调节的血清素能机制也可降低唾液腺增生反应，主要发生在幼鼠中。给予多巴胺可增强成年小鼠的反应，使其达到幼龄动物中观察到的水平。在血清素诱导的对异丙肾上腺素增生反应的抑制情况下，脾脏活化的低密度淋巴细胞数量减少，而在反应刺激情况下则增加。先前已表明这些淋巴细胞可调节唾液腺组织对异丙肾上腺素的增殖反应。
