[γ-氨基丁酸能系统在免疫调节中与多巴胺能和5-羟色胺能系统的相互作用]
[Interaction of the GABA-ergic system with the dopaminergic and serotoninergic in immunomodulation].
作者信息
Idova G V, Beletskaia I O, Devoĭno L V
出版信息
Fiziol Zh SSSR Im I M Sechenova. 1988 Jun;74(6):865-70.
PMID:2846374
Abstract
In CBA mice immunized with sheep red blood cells, the GABA-ergic system was found to act on the immunogenesis depending on the monoaminergic systems activity. The dopaminergic system stimulating immunogenesis is predominant in activation of the GABA-ergic system, whereas the serotoninergic system mediating the inhibition of the immune response is predominant in conditions of the GABA-ergic system blockade.
摘要
在用绵羊红细胞免疫的CBA小鼠中，发现γ-氨基丁酸能系统根据单胺能系统的活性作用于免疫发生过程。刺激免疫发生的多巴胺能系统在γ-氨基丁酸能系统的激活中占主导地位，而介导免疫反应抑制的5-羟色胺能系统在γ-氨基丁酸能系统被阻断的情况下占主导地位。
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