体外鼻咽部细菌诱导人腺样体淋巴细胞对免疫球蛋白分泌的多克隆激活。
Polyclonal activation to immunoglobulin secretion in human adenoid lymphocytes induced by bacteria from nasopharynx in vitro.
作者信息
Rynnel-Dagöö B
出版信息
Clin Exp Immunol. 1978 Dec;34(3):402-10.
Adenoid lymphocytes from twenty-six children scheduled consecutively for adenoidectomy because of severe nasal obstruction were stimulated by and haemolytic streptococci group A. All bacteria induced both increased DNA synthesis and polyclonal antibody secretion, tested in a haemolytic plaque assay. The magnitude of the B-cell response was correlated to the age of the children. Thus, cells from older children showed a significantly higher polyclonal response than those from younger children. No case of unresponsiveness to any stimulant was observed. Susceptibility to infection was more pronounced among the younger children, which might reflect some degree of immaturity in the immune system. However, adenoid lymphocytes are immunocompetent cells, contributing to antibody secretion in the response against infection. The role of the receptor for PBA substances on adenoid cells in immune reactions against infectious micro-organisms is discussed.
对连续26名因严重鼻塞而计划接受腺样体切除术的儿童的腺样体淋巴细胞，用A组溶血性链球菌进行刺激。在溶血空斑试验中检测发现，所有细菌均诱导DNA合成增加和多克隆抗体分泌。B细胞反应的强度与儿童年龄相关。因此，年龄较大儿童的细胞比年龄较小儿童的细胞表现出明显更高的多克隆反应。未观察到对任何刺激物无反应的情况。年幼儿童的感染易感性更明显，这可能反映出免疫系统存在一定程度的不成熟。然而，腺样体淋巴细胞是具有免疫活性的细胞，在抗感染反应中有助于抗体分泌。本文讨论了腺样体细胞上PBA物质受体在针对感染性微生物的免疫反应中的作用。
Zotero 插件