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比较住院后两种医学定制膳食的持续时间:一项随机临床试验。

Comparing two durations of medically tailored meals posthospitalization: A randomized clinical trial.

机构信息

Department of Medicine, Division of Geriatrics, Hospice and Palliative Care, University of California, Davis, California, USA.

Institute for Health Research, Kaiser Permanente of Colorado, Aurora, Colorado, USA.

出版信息

J Hosp Med. 2023 Jul;18(7):576-587. doi: 10.1002/jhm.13084. Epub 2023 Mar 28.

Abstract

BACKGROUND

Medically tailored meals (MTM) may be beneficial to patients after hospital discharge.

OBJECTIVE

To determine if 2 versus 4 weeks of MTM posthospitalization will improve patient outcomes.

DESIGN

Randomized unblinded trial.

SETTINGS AND PARTICIPANTS

Six hundred and fifty patients pending hospital discharge with at least one chronic condition.

INTERVENTION

One MTM a day for 2 versus 4 weeks.

MAIN OUTCOME AND MEASURES

The primary outcome was a change from baseline to 60 days in the Hospital Anxiety Depression Scale (HADS). Secondary outcomes measured change in the Katz activities of daily living (ADLs), DETERMINE nutritional risk, and all-cause emergency department (ED) visits and rehospitalizations.

RESULTS

From baseline to 60 days the HADS anxiety subscale changed 5.4-4.9 in the 2-week group (p = .03) and 5.4-5.3 in the 4-week group (p = .49); the difference in change between groups 0.4 (p = .25). HADS changed 5.4-4.8 in the 2-week group (p = .005) and 5.3-5.1 in the 4-week group (p = .34); the difference in change between groups 0.4 (p = .18). ADL score changed from 5.3 to 5.6 in the 2-week group (p ≤ .0001) and 5.2-5.5 in the 4-week group (p ≤ .0001); the difference in change between groups -0.01 (p = .90). The DETERMINE changed in the 2-week group from 7.2 to 6.4 (p = .0006) and from 7 to 6.7 in the 4-week group (p = .19); the difference in change between groups 0.5 (p = .13). There was no difference in ED visits and rehospitalizations between groups or time to rehospitalization.

CONCLUSIONS

Different durations of short-term MTM did not affect patient-centered or utilization outcomes.

摘要

背景

医疗定制膳食(MTM)可能有益于出院后的患者。

目的

确定住院后接受 2 周或 4 周 MTM 是否会改善患者的预后。

设计

随机非盲试验。

地点和参与者

650 名即将出院且至少有一种慢性病的患者。

干预措施

每天接受 1 份 MTM,持续 2 周或 4 周。

主要结局和测量指标

主要结局是从基线到 60 天,采用医院焦虑抑郁量表(HADS)评估的变化。次要结局包括 Katz 日常生活活动(ADL)、DETERMINE 营养风险以及全因急诊就诊和再入院的变化。

结果

从基线到 60 天,2 周组 HADS 焦虑分量表的变化为 5.4-4.9(p = .03),4 周组的变化为 5.4-5.3(p = .49);两组间的变化差异为 0.4(p = .25)。2 周组 HADS 的变化为 5.4-4.8(p = .005),4 周组的变化为 5.3-5.1(p = .34);两组间的变化差异为 0.4(p = .18)。ADL 评分在 2 周组从 5.3 变为 5.6(p ≤ .0001),在 4 周组从 5.2 变为 5.5(p ≤ .0001);两组间的变化差异为-0.01(p = .90)。2 周组的 DETERMINE 从 7.2 变为 6.4(p = .0006),4 周组从 7 变为 6.7(p = .19);两组间的变化差异为 0.5(p = .13)。两组之间的急诊就诊和再入院率或再入院时间无差异。

结论

MTM 短期持续时间不同并不影响以患者为中心的结局或利用情况。

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