MacMillan J F, Gold A, Crow T J, Johnson A L, Johnstone E C
Br J Psychiatry. 1986 Feb;148:133-43. doi: 10.1192/bjp.148.2.133.
The relatives of 82 patients in a study of first episodes of schizophrenia were interviewed within six weeks of the index admission; 77 patients were subsequently discharged, and were followed to relapse or readmission. Analysis of relapse-free survival time was used to examine whether the components of 'expressed emotion' predicted relapse or response to neuroleptic medication: 'critical comments' by relatives was the only component present often enough to be used and was inversely related to 'social contact'. When preadmission duration of illness, and neuroleptic medication following discharge (identified previously as significant predictors of outcome) were taken into account, neither 'critical comments' nor 'social contact' were related to outcome nor to response to medication. The constellation of factors suggested as pathogenic was present only in a minority of cases: many patients lived alone and of those that were with families, most were not in high face-to-face contact with other members. The failure of the components of 'expressed emotion' to predict outcome or response to neuroleptic medication suggests that at best, such factors are weak predictors of liability to relapse. Their influence is unlikely to be comparable in magnitude to that of neuroleptic medication.
在一项关于精神分裂症首发患者的研究中,对82名患者的亲属在索引入院后的六周内进行了访谈;随后77名患者出院,并随访至复发或再次入院。采用无复发生存时间分析来检验“情感表达”的各个成分是否能预测复发或对抗精神病药物的反应:亲属的“批评性评论”是唯一出现频率足够高且可用于分析的成分,并且与“社会接触”呈负相关。当考虑入院前的病程以及出院后的抗精神病药物治疗(先前已确定为结局的重要预测因素)时,“批评性评论”和“社会接触”均与结局或药物反应无关。被认为具有致病性的因素组合仅在少数病例中存在:许多患者独居,而那些与家人同住的患者中,大多数与其他家庭成员没有频繁的面对面接触。“情感表达”的各个成分未能预测结局或对抗精神病药物的反应,这表明这些因素充其量只是复发易感性的弱预测指标。它们的影响在程度上不太可能与抗精神病药物的影响相媲美。