Davidson T, Westbury G, Harmer C L
Br J Surg. 1986 Apr;73(4):308-9. doi: 10.1002/bjs.1800730420.
Twenty patients with soft-tissue sarcomas arising within previously irradiated fields have been analysed. The initial radiation dose ranged from 8.8 to 70 Gy, comprising either orthovoltage or megavoltage treatment. The latent interval following radiotherapy ranged from 7 to 45 years (mean 16.8 years). The commonest histological subtype was malignant fibrous histiocytoma. Four patients required forequarter amputation. The 5-year survival was only 14 per cent. The high morbidity and mortality accompanying post-radiation sarcomas must be borne in mind when the choice between therapeutic options for potentially curable cancers is finely balanced.
对20例在先前放疗区域内发生软组织肉瘤的患者进行了分析。初始放疗剂量为8.8至70 Gy，包括深部X线治疗或兆伏级治疗。放疗后的潜伏期为7至45年（平均16.8年）。最常见的组织学亚型是恶性纤维组织细胞瘤。4例患者需要进行上肢截肢术。5年生存率仅为14%。当可治愈癌症的治疗方案选择处于微妙平衡时，必须牢记放疗后肉瘤所伴随的高发病率和死亡率。
