Pranoto Adi, Cahyono Maulana Bagus Adi, Yakobus Reinaldi, Izzatunnisa Nabilah, Ramadhan Roy Novri, Rejeki Purwo Sri, Miftahussurur Muhammad, Effendi Wiwin Is, Wungu Citrawati Dyah Kencono, Yamaoka Yoshio
Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.
Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.
Sports (Basel). 2023 Feb 27;11(3):54. doi: 10.3390/sports11030054.
A sedentary lifestyle and an unhealthy diet increase the risk of obesity. People with obesity experience adipocyte hypertrophy and hyperplasia, which increases the production of proinflammatory cytokines, thereby increasing the risk of morbidity and mortality. Lifestyle modification using non-pharmacological approaches such as physical exercise prevents increased morbidity through its anti-inflammatory effects. The purpose of this study was to examine the effects of different types of exercise on decreased proinflammatory cytokines in young adult females with obesity. A total of 36 female students from Malang City aged 21.86 ± 1.39 years with body mass index (BMI) of 30.93 ± 3.51 kg/m were recruited and followed three different types of exercise interventions: moderate-intensity endurance training (MIET), moderate-intensity resistance training (MIRT), and moderate-intensity combined training (MICT). The exercise was performed at a frequency of 3x/week for 4 weeks. Statistical analysis was performed using the Statistical Package for Social Science (SPSS) version 21.0, using the paired sample -test. The results revealed that serum IL-6 and TNF-α levels were significantly decreased between pre-training and post-training in the three types of exercise (MIET, MIRT, and MICT) ( ≤ 0.001). The percentage change in IL-6 levels from pre-training in CTRL was (0.76 ± 13.58%), in MIET was (-82.79 ± 8.73%), in MIRT was (-58.30 ± 18.05%), in MICT was (-96.91 ± 2.39%), and ( ≤ 0.001). There was a percentage change in TNF-α levels from pre-training in CTRL (6.46 ± 12.13%), MIET (-53.11 ± 20.02%), MIRT (-42.59 ± 21.64%), and MICT (-73.41 ± 14.50%), and ( ≤ 0.001). All three types of exercise consistently reduced proinflammatory cytokines such as serum levels of IL-6 and TNF-α.
久坐不动的生活方式和不健康的饮食会增加肥胖风险。肥胖者会经历脂肪细胞肥大和增生，这会增加促炎细胞因子的产生，从而增加发病和死亡风险。采用体育锻炼等非药物方法进行生活方式干预，可通过其抗炎作用预防发病率增加。本研究的目的是探讨不同类型运动对肥胖年轻成年女性促炎细胞因子减少的影响。共招募了36名来自玛琅市的女学生，年龄为21.86±1.39岁，体重指数（BMI）为30.93±3.51kg/m²，并对她们进行了三种不同类型的运动干预：中等强度耐力训练（MIET）、中等强度阻力训练（MIRT）和中等强度联合训练（MICT）。运动频率为每周3次，共进行4周。使用社会科学统计软件包（SPSS）21.0版进行统计分析，采用配对样本t检验。结果显示，三种运动类型（MIET、MIRT和MICT）在训练前和训练后血清IL-6和TNF-α水平均显著降低（P≤0.001）。对照组IL-6水平相对于训练前的百分比变化为（0.76±13.58%），MIET组为（-82.79±8.73%），MIRT组为（-58.30±18.05%），MICT组为（-96.91±2.39%），且P≤0.001。对照组TNF-α水平相对于训练前的百分比变化为（6.46±12.13%），MIET组为（-53.11±20.02%），MIRT组为（-42.59±21.64%），MICT组为（-73.41±14.50%），且P≤0.001。所有三种运动类型均能持续降低促炎细胞因子，如血清IL-6和TNF-α水平。
