Chomanskis Žilvinas, Jonkus Vytautas, Danielius Tadas, Paulauskas Tomas, Orvydaitė Monika, Melaika Kazimieras, Rukšėnas Osvaldas, Hendrixson Vaiva, Ročka Saulius
Clinic of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, Lithuania.
Department of Neurosurgery, Vilnius University Hospital Santaros Klinikos, LT-08406 Vilnius, Lithuania.
Brain Sci. 2023 Mar 16;13(3):504. doi: 10.3390/brainsci13030504.
The control circuits of blood pressure have a strong neural regulatory element important in the pathogenesis of essential drug-resistant hypertension. Targeting lower medullary neural control mechanisms of blood pressure by electrical stimulation could be beneficial, and therefore, a novel device is needed. This paper presents a remotely programmable deep brain stimulator with an invasive continuous blood pressure monitoring system in a non-tethered rat model. The device is designed for lower medullary deep brain stimulation research with minimal interference to a daily animal routine. Electrodes were implanted in the caudal ventrolateral medulla. Animal survivability, catheter patency rates, and device data drift were evaluated. Eight out of ten rats survived the surgery and testing period with no or mild temporary neurological compromise. The study revealed that carotid catheters filled with heparinized glycerol ensure better catheter patency rates and blood pressure transduction. There was no significant drift in the device's pressure sensitivity during the experiment. To our knowledge, this is the first experimental study to show considerable animal survival after lower medullary implantation. Combining the ability to measure and monitor invasive blood pressure with a closed-loop brain pulse generator in a single device could be of potential value in future hemodynamic animal research.
血压控制回路具有强大的神经调节成分，在原发性耐药性高血压的发病机制中起重要作用。通过电刺激靶向延髓下部的血压神经控制机制可能有益，因此，需要一种新型装置。本文介绍了一种在非束缚大鼠模型中具有侵入性连续血压监测系统的远程可编程深部脑刺激器。该装置专为延髓下部深部脑刺激研究而设计，对动物日常活动的干扰最小。电极植入尾侧腹外侧延髓。评估了动物的存活率、导管通畅率和装置数据漂移情况。十只大鼠中有八只在手术和测试期存活，没有或仅有轻微的暂时性神经功能损害。研究表明，填充肝素化甘油的颈动脉导管可确保更好的导管通畅率和血压传导。实验期间，该装置的压力敏感性没有明显漂移。据我们所知，这是第一项显示延髓下部植入后动物存活率较高的实验研究。在单个装置中结合测量和监测侵入性血压的能力与闭环脑脉冲发生器，在未来的血流动力学动物研究中可能具有潜在价值。
