Fu Changzhen, Xu Jianming, Chen Shao-Lang, Chen Chong-Bo, Liang Jia-Jian, Liu Zibo, Huang Chukai, Wu Zhenggen, Ng Tsz Kin, Zhang Mingzhi, Liu Qingping
Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Int J Mol Sci. 2024 Apr 21;25(8):4544. doi: 10.3390/ijms25084544.
To investigate the plasma lipoprotein subclasses in patients with primary open-angle glaucoma (POAG), a total of 20 Chinese POAG patients on intraocular pressure (IOP)-lowering treatment and 20 age-matched control subjects were recruited. Based on the levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), the study subjects were divided into elevated- and normal-level subgroups. The plasma lipoprotein, lipoprotein subclasses, and oxidized LDL (oxLDL) levels were quantitatively measured. The discrimination potential of the lipoproteins was evaluated using the area under the receiver operating characteristic curve (AUC), and their correlation with clinical parameters was also evaluated. Compared to the control subjects with elevated TC and/or LDL-C levels, the levels of TC, LDL-C, non-high-density lipoprotein cholesterol (non-HDL), LDL subclass LDL3 and small dense LDL (sdLDL), and oxLDL were significantly higher in POAG patients with elevated TC and/or LDL-C levels. No differences in any lipoproteins or the subclasses were found between the POAG patients and control subjects with normal TC and LDL-C levels. Moderate-to-good performance of TC, LDL-C, non-HDL, LDL3, sdLDL, and oxLDL was found in discriminating between the POAG patients and control subjects with elevated TC and/or LDL-C levels (AUC: 0.710-0.950). Significant negative correlations between LDL3 and sdLDL with retinal nerve fiber layer (RNFL) thickness in the superior quadrant and between LDL3 and average RNFL thickness were observed in POAG patients with elevated TC and/or LDL-C levels. This study revealed a significant elevation of plasma lipoproteins, especially the LDL subclasses, in POAG patients with elevated TC and/or LDL-C levels, providing insights on monitoring specific lipoproteins in POAG patients with elevated TC and/or LDL-C.
为了研究原发性开角型青光眼（POAG）患者的血浆脂蛋白亚类，我们招募了20名正在接受降眼压治疗的中国POAG患者以及20名年龄匹配的对照受试者。根据总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平，将研究对象分为升高水平亚组和正常水平亚组。对血浆脂蛋白、脂蛋白亚类和氧化型LDL（oxLDL）水平进行定量测定。使用受试者工作特征曲线下面积（AUC）评估脂蛋白的鉴别潜力，并评估其与临床参数的相关性。与TC和/或LDL-C水平升高的对照受试者相比，TC、LDL-C、非高密度脂蛋白胆固醇（非HDL）、LDL亚类LDL3和小而密LDL（sdLDL）以及oxLDL水平在TC和/或LDL-C水平升高的POAG患者中显著更高。在TC和LDL-C水平正常的POAG患者与对照受试者之间，未发现任何脂蛋白或亚类存在差异。在鉴别TC和/或LDL-C水平升高的POAG患者与对照受试者方面，发现TC、LDL-C、非HDL、LDL3、sdLDL和oxLDL具有中度至良好的表现（AUC：0.710 - 0.950）。在TC和/或LDL-C水平升高的POAG患者中，观察到LDL3和sdLDL与上象限视网膜神经纤维层（RNFL）厚度之间以及LDL3与平均RNFL厚度之间存在显著负相关。这项研究揭示了TC和/或LDL-C水平升高的POAG患者血浆脂蛋白尤其是LDL亚类显著升高，为监测TC和/或LDL-C水平升高的POAG患者的特定脂蛋白提供了见解。
