Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, 8010 Graz, Austria.
ACIB-Austrian Centre of Industrial Biotechnology, 8010 Graz, Austria.
Biomolecules. 2023 Feb 26;13(3):441. doi: 10.3390/biom13030441.
Since the mid-1960s, methylotrophic yeast (previously described as ) has received increasing scientific attention. The interest for the industrial production of proteins for different applications (e.g., feed, food additives, detergent, waste treatment processes, and textile) is a well-consolidated scientific topic, and the importance for this approach is rising in the current era of environmental transition in human societies. This review aims to summarize fundamental and specific information in this scientific field. Additionally, an updated description of the relevant products produced with . at industrial levels by a variety of companies-describing how the industry has leveraged its key features, from products for the ingredients of meat-free burgers (e.g., IMPOSSIBLE™ FOODS, USA) to diabetes therapeutics (e.g., Biocon, India)-is provided. Furthermore, active patents and the typical workflow for industrial protein production with this strain are reported.
自 20 世纪 60 年代中期以来,甲醇营养型酵母(以前被描述为 )越来越受到科学界的关注。对于不同应用(例如饲料、食品添加剂、洗涤剂、废物处理过程和纺织品)的蛋白质的工业生产的兴趣是一个成熟的科学课题,并且在人类社会向环境转型的当前时代,这种方法的重要性正在上升。本文旨在总结该科学领域的基础和具体信息。此外,还提供了通过各种公司在工业水平上用生产的相关产品的最新描述,介绍了该行业如何利用其关键特性,从无肉汉堡的成分产品(例如,美国的 IMPOSSIBLE™ FOODS)到糖尿病治疗药物(例如,印度的 Biocon)。此外,还报告了该菌株用于工业蛋白质生产的有效专利和典型工作流程。