染料（靛蓝胭脂红、间苯二胺黄、亮绿FCF）和亚硝酸盐在体内对小鼠骨髓染色体的影响。

Effects of dyes (indigo carmine, metanil yellow, fast green FCF) and nitrite in vivo on bone marrow chromosomes of mice.

作者信息

Giri A K, Banerjee T S, Talukder G, Sharma A

出版信息

Cancer Lett. 1986 Mar;30(3):315-20. doi: 10.1016/0304-3835(86)90056-x.

Abstract

Effects of 3 dyes in combination with nitrite were studied on bone marrow chromosomes of mice following prolonged oral treatment. The dyes were namely, Indigo Carmine and Metanil Yellow, both of which contain a secondary amino group, and Fast Green FCF, which has a tertiary amino group. All dyes produced aberrations but Metanil Yellow showed stronger clastogenic activity than Fast Green FCF and Indigo Carmine. Nitrite alone also induced strong clastogenic activity. A combination of dye and nitrite half the normal concentrations produced synergistic effects, which may be ascribed to the formation of nitrosamines.

摘要

在长期口服给药后，研究了三种染料与亚硝酸盐联合使用对小鼠骨髓染色体的影响。这三种染料分别是靛蓝胭脂红和甲基黄，二者均含有仲氨基，还有亮绿FCF，其含有叔氨基。所有染料均能产生畸变，但甲基黄显示出比亮绿FCF和靛蓝胭脂红更强的致断裂活性。单独的亚硝酸盐也能诱导强烈的致断裂活性。染料与正常浓度一半的亚硝酸盐联合使用产生协同效应，这可能归因于亚硝胺的形成。