体内单独及联合使用间硝基苯黄酸和亚硝酸盐对小鼠诱导的姐妹染色单体交换

Sister chromatid exchange induced by metanil yellow and nitrite singly and in combination in vivo on mice.

作者信息

Giri A K, Talukder G, Sharma A

出版信息

Cancer Lett. 1986 Jun;31(3):299-303. doi: 10.1016/0304-3835(86)90151-5.

Abstract

In vivo sister chromatid exchanges (SCEs) induced by metanil yellow (a dye containing secondary amino group), sodium nitrite, and dye in combination with nitrite following treatment with acute doses were studied on mice. The incidence of SCEs was significantly high in both dye- and nitrite-treated series. However, a combination of half the concentrations of dye and nitrite, when used together, gave a frequency of SCE higher than that of either chemical, when given in full dose, indicating the stronger clastogenicity of the nitrosamine formed.

摘要

研究了急性剂量处理后，间胺黄（一种含仲氨基的染料）、亚硝酸钠以及染料与亚硝酸盐联合作用对小鼠体内姐妹染色单体交换（SCEs）的影响。在染料处理组和亚硝酸盐处理组中，SCEs的发生率均显著升高。然而，当染料和亚硝酸盐各用一半浓度联合使用时，所产生的SCE频率高于各自使用全剂量时的频率，这表明所形成的亚硝胺具有更强的致断裂性。