等离子体调制上转换生物传感器。

Plasmon Modulated Upconversion Biosensors.

机构信息

Institute of Advanced Organic Materials, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Republic of Korea.

School of Chemical Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Republic of Korea.

出版信息

Biosensors (Basel). 2023 Feb 22;13(3):306. doi: 10.3390/bios13030306.

DOI:10.3390/bios13030306

PMID:36979518

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10046391/

Abstract

Over the past two decades, lanthanide-based upconversion nanoparticles (UCNPs) have been fascinating scientists due to their ability to offer unprecedented prospects to upconvert tissue-penetrating near-infrared light into color-tailorable optical illumination inside biological matter. In particular, luminescent behavior UCNPs have been widely utilized for background-free biorecognition and biosensing. Currently, a paramount challenge exists on how to maximize NIR light harvesting and upconversion efficiencies for achieving faster response and better sensitivity without damaging the biological tissue upon laser assisted photoactivation. In this review, we offer the reader an overview of the recent updates about exciting achievements and challenges in the development of plasmon-modulated upconversion nanoformulations for biosensing application.

摘要

在过去的二十年中，基于镧系元素的上转换纳米粒子（UCNPs）因其能够将组织穿透性近红外光上转换为生物体内可调节颜色的光学照明的能力而引起了科学家的极大兴趣。特别是，UCNPs 的发光行为已被广泛用于无背景的生物识别和生物传感。目前，最大的挑战是如何最大限度地提高近红外光的收集和上转换效率，以实现更快的响应和更好的灵敏度，而不会在激光辅助光激活时损坏生物组织。在这篇综述中，我们为读者提供了关于等离子体调制上转换纳米制剂在生物传感应用中的令人兴奋的最新研究进展和挑战的概述。