Manogna K Sai, Kusuma K, Reddy G Rajasekhara, Raju B Deva Prasad, Sushma N John
Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam, (Women's University), Tirupati, 517 502, India.
School of Mechanical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Biotechnol Rep (Amst). 2025 Aug 15;48:e00916. doi: 10.1016/j.btre.2025.e00916. eCollection 2025 Dec.
Neodymium (Nd³⁺) doped hydroxyapatite nanoparticles (Han: Nd³⁺ NPs) were synthesized and systematically characterized to evaluate their structural and functional properties for biomedical applications. X-ray diffraction (XRD) confirmed the crystalline phase retention post-doping, while x-ray photoelectron spectroscopy (XPS) revealed the successful incorporation of Nd³⁺ ions. The doping altered the optical and electronic properties, potentially enhancing bioactivity and imaging capabilities. Preliminary cytotoxicity assessments on MCF7 and 4T1 breast cancer cell lines indicated dose-dependent effects, with IC50 values of 36.13 µg/mL and 64.38 µg/mL, respectively. The study concludes that Han: Nd³⁺ NPs offer promise as multifunctional platforms for cytotoxic response and structural stability, with potential for future application in imaging and targeted breast cancer therapy.
合成了掺钕（Nd³⁺）的羟基磷灰石纳米颗粒（Han: Nd³⁺ NPs），并对其进行了系统表征，以评估其在生物医学应用中的结构和功能特性。X射线衍射（XRD）证实了掺杂后晶体相的保留，而X射线光电子能谱（XPS）显示Nd³⁺离子成功掺入。掺杂改变了光学和电子特性，有可能增强生物活性和成像能力。对MCF7和4T1乳腺癌细胞系的初步细胞毒性评估表明存在剂量依赖性效应，IC50值分别为36.13 µg/mL和64.38 µg/mL。该研究得出结论，Han: Nd³⁺ NPs有望作为多功能平台用于细胞毒性反应和结构稳定性，未来有可能应用于成像和靶向乳腺癌治疗。
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