Paulus Theresa, Wernecke Lynn, Lundie Annik, Friedrich Julia, Verrel Julius, Rawish Tina, Weissbach Anne, Frings Christian, Beste Christian, Bäumer Tobias, Münchau Alexander
Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany.
Department of Neurology, University of Lübeck, 23562 Lübeck, Germany.
Biomedicines. 2023 Mar 22;11(3):980. doi: 10.3390/biomedicines11030980.
Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in the Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigated the immediate effects of single-session 1 Hz rTMS and sham stimulation delivered to the left BA40 on tics assessed with the Rush video protocol in 29 adults with GTS. There were no significant effects on tic symptoms following rTMS or sham stimulation. Moreover, there was no difference when comparing the effects of both stimulation conditions. Bayesian statistics indicated substantial evidence against an intervention effect. The left BA40 appears not to be a useful target for 1 Hz rTMS to modulate tic symptoms in GTS patients.
左侧顶下小叶皮质（BA40）活动增加在抽动秽语综合征（GTS）的抽动产生中起作用。因此，有人推测，应用于BA40的抑制性重复经颅磁刺激（rTMS）可缓解GTS症状。我们采用拉什视频方案，研究了对29名成年GTS患者左侧BA40进行单节次1Hz rTMS和伪刺激对抽动的即时影响。rTMS或伪刺激后抽动症状均无显著影响。此外，比较两种刺激条件的效果时没有差异。贝叶斯统计表明有大量证据反对干预效应。左侧BA40似乎不是1Hz rTMS调节GTS患者抽动症状的有效靶点。
