PAK4和PHF8的表达模式与胆囊癌患者的生存情况相关。

Expression Patterns of PAK4 and PHF8 Are Associated with the Survival of Gallbladder Carcinoma Patients.

作者信息

Ahn Ae Ri, Karamikheirabad Maryam, Park Min Su, Zhang Junyue, Kim Hyun Sun, Jeong Ji Su, Kim Kyoung Min, Park Ho Sung, Jang Kyu Yun

机构信息

Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.

Department of Medicine, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.

出版信息

Diagnostics (Basel). 2023 Mar 17;13(6):1149. doi: 10.3390/diagnostics13061149.

DOI:10.3390/diagnostics13061149

PMID:36980457

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10047028/

Abstract

BACKGROUND

PAK4 and PHF8 are involved in cancer progression and are under evaluation as targets for cancer therapy. However, despite extensive studies in human cancers, there are limited reports on the roles of PAK4 and PHF8 in gallbladder cancers.

METHODS

Immunohistochemical expression of PAK4 and PHF8 and their prognostic significance were evaluated in 148 human gallbladder carcinomas.

RESULTS

PAK4 expression was significantly associated with PHF8 expression in gallbladder carcinomas. Positive expression of nuclear PAK4, cytoplasmic PAK4, nuclear PHF8, and cytoplasmic PHF8 were significantly associated with shorter overall survival and relapse-free survival in univariate analysis. Multivariate analysis showed that nuclear PAK4 expression and nuclear PHF8 expression were independent predictors of overall survival and relapse-free survival in gallbladder carcinomas. Furthermore, coexpression of nuclear PAK4 and nuclear PHF8 predicted shorter overall survival ( 0.001) and relapse-free survival ( 0.001) of gallbladder carcinoma in multivariate analysis.

CONCLUSIONS

This study suggests that the individual and coexpression patterns of PAK4 and PHF8 as the prognostic indicators for gallbladder carcinoma patients.

摘要

背景

PAK4和PHF8参与癌症进展，正在作为癌症治疗靶点进行评估。然而，尽管在人类癌症方面进行了广泛研究，但关于PAK4和PHF8在胆囊癌中的作用的报道有限。

方法

对148例人类胆囊癌组织中PAK4和PHF8的免疫组化表达及其预后意义进行评估。

结果

在胆囊癌中，PAK4表达与PHF8表达显著相关。在单因素分析中，核PAK4、胞质PAK4、核PHF8和胞质PHF8的阳性表达均与较短的总生存期和无复发生存期显著相关。多因素分析显示，核PAK4表达和核PHF8表达是胆囊癌总生存期和无复发生存期的独立预测因素。此外，在多因素分析中，核PAK4和核PHF8的共表达预示着胆囊癌患者较短的总生存期（P<0.001）和无复发生存期（P<0.001）。