Faculty of Chemistry, University of Opole, 45-052 Opole, Poland.
Department of Drug Forms Technology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Int J Environ Res Public Health. 2023 Mar 8;20(6):4780. doi: 10.3390/ijerph20064780.
Facial makeup cosmetics are commonly used products that are applied to the skin, and their ingredients come into contact with it for many years. Consequently, they should only contain substances that are considered safe or used within an allowable range of established concentrations. According to current European laws, all cosmetics approved for use should be entirely safe for their users, and the responsibility for this lies with manufacturers, distributors, and importers. However, the use of cosmetics can be associated with undesirable effects due to the presence of certain chemical substances. An analysis of 50 random facial makeup cosmetics commercially available on the European Union market and manufactured in six European countries was carried out, concerning the presence of substances with potential carcinogenic properties, as described in recent years in the literature. Nine types of facial makeup cosmetics were selected, and their compositions, as declared on the labels, were analyzed. The carcinogens were identified with information present in the European CosIng database and according to the Insecticide Resistance Action Committee's (IRAC) classification. As a result, the following potential carcinogens were identified: parabens (methylparaben, propylparaben, butylparaben, and ethylparaben), ethoxylated compounds (laureth-4, lautreth-7, or ethylene glycol polymers known as PEG), formaldehyde donors (imidazolidinyl urea, quaternium 15, and DMDM hydantoin), and ethanolamine and their derivatives (triethanolamine and diazolidinyl urea), as well as carbon and silica. In conclusion, all of the analyzed face makeup cosmetics contain potential carcinogenic substances. The literature review confirmed the suppositions regarding the potential carcinogenic effects of selected cosmetic ingredients. Therefore, it seems necessary to carry out studies on the long-term exposure of compounds present in cosmetics and perhaps introduce stricter standards and laws regulating the potential presence of carcinogens and their activity in cosmetics.
面部彩妆化妆品是一种常用的产品，涂抹于皮肤之上，其成分与之接触多年。因此，其成分仅应包含被认为是安全的或在既定浓度范围内使用的物质。根据现行欧洲法律，所有获准使用的化妆品都应该对其使用者完全安全，这一责任在于制造商、分销商和进口商。然而，由于某些化学物质的存在，化妆品的使用可能会带来不良影响。对在欧洲联盟市场上销售的、产自六个欧洲国家的 50 种随机面部彩妆化妆品进行了分析，以检测文献中近年来所描述的具有潜在致癌特性的物质。选择了九种类型的面部彩妆化妆品，分析了其标签上所宣称的成分。利用欧洲化妆品成分数据库中的信息以及杀虫剂抗药性行动委员会（IRAC）的分类来识别致癌物质。结果发现了以下潜在的致癌物质：对羟基苯甲酸酯（甲基对羟基苯甲酸酯、丙基对羟基苯甲酸酯、丁基对羟基苯甲酸酯和乙基对羟基苯甲酸酯）、乙氧基化合物（月桂醇聚醚-4、月桂醇聚醚-7 或聚乙二醇）、甲醛供体（咪唑烷基脲、季铵盐 15 和 DMDM 乙内酰脲）、乙醇胺及其衍生物（三乙醇胺和二羟甲基二氢尿嘧啶）以及碳和硅。总之，所有分析的面部彩妆化妆品都含有潜在的致癌物质。文献综述证实了关于某些化妆品成分具有潜在致癌作用的假设。因此，似乎有必要对化妆品中存在的化合物的长期暴露进行研究，并可能引入更严格的标准和法规来监管化妆品中潜在致癌物质及其活性。
