Division of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital-Keelung, Keelung 20401, Taiwan.
Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Int J Mol Sci. 2023 Mar 13;24(6):5499. doi: 10.3390/ijms24065499.
Disorders of the immune system, including immunodeficiency, immuno-malignancy, and (auto)inflammatory, autoimmune, and allergic diseases, have a great impact on a host's health. Cellular communication mediated through cell surface receptors, among different cell types and between cell and microenvironment, plays a critical role in immune responses. Selective members of the adhesion G protein-coupled receptor (aGPCR) family are expressed differentially in diverse immune cell types and have been implicated recently in unique immune dysfunctions and disorders in part due to their dual cell adhesion and signaling roles. Here, we discuss the molecular and functional characteristics of distinctive immune aGPCRs and their physiopathological roles in the immune system.
免疫系统疾病，包括免疫缺陷、免疫恶性肿瘤以及（自身）炎症、自身免疫和过敏疾病，对宿主健康有重大影响。不同细胞类型之间以及细胞与微环境之间通过细胞表面受体进行的细胞通讯在免疫反应中起着关键作用。黏附 G 蛋白偶联受体（aGPCR）家族的选择性成员在不同的免疫细胞类型中表达不同，最近由于其双重细胞黏附和信号作用，被认为与某些独特的免疫功能障碍和疾病有关。在这里，我们讨论了独特的免疫 aGPCR 的分子和功能特征及其在免疫系统中的生理病理作用。
