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人诱导多能干细胞衍生细胞作为药物发现 2.0 的模型。

hiPSC-Derived Cells as Models for Drug Discovery 2.0.

机构信息

The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.

Dead Sea & Arava Science Center, Masada 8691000, Israel.

出版信息

Int J Mol Sci. 2023 Mar 17;24(6):5727. doi: 10.3390/ijms24065727.

DOI:10.3390/ijms24065727
PMID:36982801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10053529/
Abstract

Human-induced pluripotent stem cells (hiPSCs) serve as a sustainable resource for studying the molecular foundation of disease development, including initiation and deterioration [...].

摘要

人类诱导多能干细胞(hiPSCs)是研究疾病发展的分子基础(包括起始和恶化)的可持续资源。

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hiPSC-Derived Cells as Models for Drug Discovery 2.0.人诱导多能干细胞衍生细胞作为药物发现 2.0 的模型。
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Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts.骨髓细胞、毛发角蛋白细胞和皮肤成纤维细胞来源的人诱导多能干细胞的比较研究。
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本文引用的文献

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Dysregulated Cell Homeostasis and miRNAs in Human iPSC-Derived Cardiomyocytes from a Propionic Acidemia Patient with Cardiomyopathy.丙酸血症心肌病患者诱导多能干细胞来源心肌细胞中的细胞稳态失调和 miRNA
Int J Mol Sci. 2023 Jan 22;24(3):2182. doi: 10.3390/ijms24032182.
2
PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux.PLEKHM2 功能丧失通过调节自噬通量来影响 iPSC 衍生神经元的活性。
Int J Mol Sci. 2022 Dec 17;23(24):16092. doi: 10.3390/ijms232416092.
3
Vesicular Glutamate Release from Feeder-FreehiPSC-Derived Neurons.无饲养层条件下诱导多能干细胞源性神经元的囊泡谷氨酸释放。
Int J Mol Sci. 2022 Sep 11;23(18):10545. doi: 10.3390/ijms231810545.
4
Efficient and Easy Conversion of Human iPSCs into Functional Induced Microglia-like Cells.高效且简便地将人诱导多能干细胞转化为功能性诱导小胶质细胞样细胞。
Int J Mol Sci. 2022 Apr 20;23(9):4526. doi: 10.3390/ijms23094526.
5
Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models.人多能干细胞模型对神经胶质相互作用的建模与靶向
Int J Mol Sci. 2022 Jan 31;23(3):1684. doi: 10.3390/ijms23031684.
6
Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs.转录组全基因组分析揭示了细胞外基质和整合素受体基因在人诱导多能干细胞耳神经感觉分化中的作用。
Int J Mol Sci. 2021 Oct 7;22(19):10849. doi: 10.3390/ijms221910849.
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Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex.选择性 5-羟色胺再摄取抑制剂氟西汀对人胎皮质模型中发育中的神经回路的影响。
Int J Mol Sci. 2021 Sep 28;22(19):10457. doi: 10.3390/ijms221910457.
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Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development.人诱导多能干细胞衍生的神经胶质细胞作为神经精神疾病研究和药物开发的工具
Int J Mol Sci. 2021 Sep 23;22(19):10254. doi: 10.3390/ijms221910254.
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Int J Mol Sci. 2021 Sep 22;22(19):10184. doi: 10.3390/ijms221910184.
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