人诱导多能干细胞衍生细胞作为药物发现 2.0 的模型。
hiPSC-Derived Cells as Models for Drug Discovery 2.0.
机构信息
The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
Dead Sea & Arava Science Center, Masada 8691000, Israel.
出版信息
Int J Mol Sci. 2023 Mar 17;24(6):5727. doi: 10.3390/ijms24065727.
Abstract
Human-induced pluripotent stem cells (hiPSCs) serve as a sustainable resource for studying the molecular foundation of disease development, including initiation and deterioration [...].
摘要
人类诱导多能干细胞（hiPSCs）是研究疾病发展的分子基础（包括起始和恶化）的可持续资源。
相似文献
1
hiPSC-Derived Cells as Models for Drug Discovery 2.0.人诱导多能干细胞衍生细胞作为药物发现 2.0 的模型。
Int J Mol Sci. 2023 Mar 17;24(6):5727. doi: 10.3390/ijms24065727.
2
Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts.骨髓细胞、毛发角蛋白细胞和皮肤成纤维细胞来源的人诱导多能干细胞的比较研究。
Eur Heart J. 2013 Sep;34(33):2618-29. doi: 10.1093/eurheartj/ehs203. Epub 2012 Jul 12.
3
Human-induced pluripotent stem cell-derived cardiomyocytes from cardiac progenitor cells: effects of selective ion channel blockade.源自心脏祖细胞的人诱导多能干细胞衍生心肌细胞：选择性离子通道阻断的作用
Europace. 2016 Dec;18(suppl 4):iv67-iv76. doi: 10.1093/europace/euw352.
4
Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells Toward a Retinal Lineage.mRNA重编程的人类诱导多能干细胞向视网膜谱系的稳健分化
Stem Cells Transl Med. 2016 Apr;5(4):417-26. doi: 10.5966/sctm.2015-0093. Epub 2016 Mar 1.
5
Reprogramming of HUVECs into induced pluripotent stem cells (HiPSCs), generation and characterization of HiPSC-derived neurons and astrocytes.将人脐静脉内皮细胞（HUVECs）重编程为诱导多能干细胞（HiPSCs），HiPSC来源的神经元和星形胶质细胞的生成及特性研究。
PLoS One. 2015 Mar 19;10(3):e0119617. doi: 10.1371/journal.pone.0119617. eCollection 2015.
6
Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells.两名克氏综合征无精子症患者诱导的多能干细胞表现出与女性多能干细胞相似的 X 染色体失活行为。
Hum Reprod. 2019 Nov 1;34(11):2297-2310. doi: 10.1093/humrep/dez134.
7
Atrial-specific hiPSC-derived cardiomyocytes in drug discovery and disease modeling.在药物发现和疾病建模中，心房特异性 hiPSC 衍生的心肌细胞。
Methods. 2022 Jul;203:364-377. doi: 10.1016/j.ymeth.2021.06.009. Epub 2021 Jun 16.
8
Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles.利用磁性纳米颗粒高效转染人诱导多能干细胞。
Int J Nanomedicine. 2018 Oct 5;13:6073-6078. doi: 10.2147/IJN.S172254. eCollection 2018.
9
Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE Perspective.多能干细胞在退行性视网膜疾病模型中的应用：RPE 视角。
Adv Exp Med Biol. 2019;1186:1-31. doi: 10.1007/978-3-030-28471-8_1.
10
Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells.人诱导多能干细胞中的持续供体细胞基因表达导致其与人胚胎干细胞存在差异。
PLoS One. 2010 Feb 1;5(2):e8975. doi: 10.1371/journal.pone.0008975.
本文引用的文献
1
Dysregulated Cell Homeostasis and miRNAs in Human iPSC-Derived Cardiomyocytes from a Propionic Acidemia Patient with Cardiomyopathy.丙酸血症心肌病患者诱导多能干细胞来源心肌细胞中的细胞稳态失调和 miRNA
Int J Mol Sci. 2023 Jan 22;24(3):2182. doi: 10.3390/ijms24032182.
2
PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux.PLEKHM2 功能丧失通过调节自噬通量来影响 iPSC 衍生神经元的活性。
Int J Mol Sci. 2022 Dec 17;23(24):16092. doi: 10.3390/ijms232416092.
3
Vesicular Glutamate Release from Feeder-FreehiPSC-Derived Neurons.无饲养层条件下诱导多能干细胞源性神经元的囊泡谷氨酸释放。
Int J Mol Sci. 2022 Sep 11;23(18):10545. doi: 10.3390/ijms231810545.
4
Efficient and Easy Conversion of Human iPSCs into Functional Induced Microglia-like Cells.高效且简便地将人诱导多能干细胞转化为功能性诱导小胶质细胞样细胞。
Int J Mol Sci. 2022 Apr 20;23(9):4526. doi: 10.3390/ijms23094526.
5
Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models.人多能干细胞模型对神经胶质相互作用的建模与靶向
Int J Mol Sci. 2022 Jan 31;23(3):1684. doi: 10.3390/ijms23031684.
6
Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs.转录组全基因组分析揭示了细胞外基质和整合素受体基因在人诱导多能干细胞耳神经感觉分化中的作用。
Int J Mol Sci. 2021 Oct 7;22(19):10849. doi: 10.3390/ijms221910849.
7
Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex.选择性 5-羟色胺再摄取抑制剂氟西汀对人胎皮质模型中发育中的神经回路的影响。
Int J Mol Sci. 2021 Sep 28;22(19):10457. doi: 10.3390/ijms221910457.
8
Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development.人诱导多能干细胞衍生的神经胶质细胞作为神经精神疾病研究和药物开发的工具
Int J Mol Sci. 2021 Sep 23;22(19):10254. doi: 10.3390/ijms221910254.
9
Complex Organ Construction from Human Pluripotent Stem Cells for Biological Research and Disease Modeling with New Emerging Techniques.利用新兴技术从人多能干细胞构建复杂器官，用于生物学研究和疾病建模。
Int J Mol Sci. 2021 Sep 22;22(19):10184. doi: 10.3390/ijms221910184.
10
Perspectives on hiPSC-Derived Muscle Cells as Drug Discovery Models for Muscular Dystrophies.人诱导多能干细胞衍生肌肉细胞作为肌肉疾病药物发现模型的观点。
Int J Mol Sci. 2021 Sep 6;22(17):9630. doi: 10.3390/ijms22179630.
Zotero 插件