身高与乳腺癌患病率呈正相关：一项对德国 135741 名女性的回顾性研究。
Positive association between body height and breast cancer prevalence: a retrospective study with 135,741 women in Germany.
机构信息
Department of Gynecology and Obstetrics, University Hospital Marburg, Philipps-University Marburg, Baldingerstraße, 35043, Marburg, Germany.
Epidemiology, IQVIA, Frankfurt, Germany.
出版信息
Breast Cancer Res Treat. 2022 Nov;196(2):349-354. doi: 10.1007/s10549-022-06730-0. Epub 2022 Sep 10.
PURPOSE
The aim of this study was to analyze the prevalence of breast cancer in relation to body height and to investigate associations between body height and breast cancer in Germany.
METHODS
This retrospective cohort study included 135,741 adult women followed in one of 161 gynecology practices in Germany between January 2019 and December 2021. The 3 year prevalence of breast cancer (ICD-10: C50) during the study period was shown in relation to body height, which was included in this study as a five-category variable for women: ≤ 160 cm, 161-165 cm, 166-170 cm, 171-175 cm, > 175 cm. The associations between height and breast cancer were analyzed using logistic regression models adjusted for age and BMI.
RESULTS
The prevalence of breast cancer increased from 5.1% in women ≤ 160 cm to 6.8% in women > 175 cm in the age group 51-60, and from 9.2% in women ≤ 160 cm to 12.2% in women 171-175 cm in the age group > 60 years. The OR for breast cancer was 1.18 (95% CI 1.12-1.24) for every 10 cm increase in height. Compared to height ≤ 160 cm, the OR for height 166-170 cm was 1.26 (1.15-1.39), for 171-175 cm 1.43 (1.27-1.61), and for > 175 cm 1.49 (1.28-1.74).
CONCLUSION
The results of this study suggest that greater body height in women is significantly related to an increased breast cancer risk.
目的
本研究旨在分析身高与乳腺癌之间的相关性，并探讨德国身高与乳腺癌之间的关联。
方法
本回顾性队列研究纳入了 2019 年 1 月至 2021 年 12 月期间在德国 161 家妇科诊所就诊的 135741 名成年女性。研究期间，展示了（ICD-10：C50）乳腺癌的 3 年患病率与身高的关系，身高在本研究中作为女性的五个类别变量进行了纳入：≤160cm、161-165cm、166-170cm、171-175cm、>175cm。使用调整年龄和 BMI 的 logistic 回归模型分析身高与乳腺癌之间的关联。
结果
在 51-60 岁年龄组中，身高≤160cm 的女性乳腺癌患病率从 5.1%上升至身高>175cm 的女性的 6.8%，而在>60 岁年龄组中，身高≤160cm 的女性乳腺癌患病率从 9.2%上升至身高 171-175cm 的女性的 12.2%。身高每增加 10cm，乳腺癌的 OR 为 1.18（95%CI 1.12-1.24）。与身高≤160cm 相比，身高 166-170cm 的 OR 为 1.26（1.15-1.39），身高 171-175cm 的 OR 为 1.43（1.27-1.61），身高>175cm 的 OR 为 1.49（1.28-1.74）。
结论
本研究结果表明，女性的身高越高，患乳腺癌的风险显著增加。
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