Plichta Piotr, Tyburski Ernest, Bielecki Maksymilian, Mak Monika, Kucharska-Mazur Jolanta, Podwalski Piotr, Rek-Owodziń Katarzyna, Waszczuk Katarzyna, Sagan Leszek, Michalczyk Anna, Misiak Błażej, Samochowiec Jerzy
Department of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, Poland.
Department of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, Poland.
J Clin Med. 2023 Mar 14;12(6):2257. doi: 10.3390/jcm12062257.
This study compared cognitive domains between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS) patients and healthy controls (HC), analyzing relationships between psychopathological dimensions and cognitive domains. A total of 29 DS patients, 45 NDS patients, and 39 HC subjects participated. Cognitive domains were measured using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Battery. Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale. Clinical groups performed poorer than HC groups in regards to speed of processing, attention/vigilance, working memory, verbal and visual learning and memory, reasoning and problem solving, and social cognition. DS patients scored poorer than NDS patients in terms of all cognitive domains and the overall score, except for reasoning and problem solving. Positive, negative, disorganization, and resistance symptoms were related to cognitive functions only in NDS patients. Our findings suggest that the MCCB battery is sensitive to detecting cognitive dysfunctions in both deficit and non-deficit schizophrenia.
本研究比较了缺陷型精神分裂症（DS）患者、非缺陷型精神分裂症（NDS）患者与健康对照（HC）之间的认知领域，分析了精神病理维度与认知领域之间的关系。共有29名DS患者、45名NDS患者和39名HC受试者参与。使用改善精神分裂症认知的测量与治疗研究电池组来测量认知领域。用阳性和阴性症状量表评估精神病理症状。在处理速度、注意力/警觉性、工作记忆、言语和视觉学习与记忆、推理和问题解决以及社会认知方面，临床组的表现比HC组差。除推理和问题解决外，DS患者在所有认知领域和总分上的得分均低于NDS患者。仅在NDS患者中，阳性、阴性、紊乱和抵抗症状与认知功能相关。我们的研究结果表明，MCCB电池组对检测缺陷型和非缺陷型精神分裂症的认知功能障碍均敏感。
