Jiang Fan, Sun Tiehui, Cheng Peng, Wang Jie, Gong Wenping
Tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Senior Department of Tuberculosis, The 8th Medical Center of PLA General Hospital, Beijing 100091, China.
The Second Brigade of Cadet, Basic Medical School, Air Force Military Medical University, Xi'an 710032, China.
J Pers Med. 2023 Feb 24;13(3):408. doi: 10.3390/jpm13030408.
Tuberculosis (TB) is an old infectious disease caused by infection. Vaccination is the most effective way to prevent and control TB. However, there is relatively little literature that systematically analyzes the progress of new TB vaccine research from a bibliometric perspective. This study was conducted to examine the development of TB vaccines over the past 20 years and to identify research priorities and directions for the future.
The Science Citation Index Expanded (SCI-E) of the Web of Science Core Collection (WOSCC) database was selected to search the literature related to TB vaccines. The countries, institutions, authors, journals, references, and keywords of each publication were analyzed and visualized using the VOSviewer, CiteSpace, and Bibliometrix software. Furthermore, GraphPad Prism and Microsoft Excel 365 were also used for statistical analysis.
As of 20 October 2022, 7960 publications related to TB vaccines were identified with 288,478 citations. The United States of America (USA) accounted for the largest share (2658, 33.40%), followed by the United Kingdom (UK, 1301, 16.34%), and China (685, 8.6%). Regarding affiliations, the University of London had the most publications (427) and shared the highest H-index (76) with the Statens Serum Institut of Denmark. In terms of the number of articles for the journals and authors, the journal Vaccine ranked first with 629 articles. Professor Peter Anderssen has published the highest number of papers (160). The burst keywords and thematic maps analysis showed that future trends in TB vaccine development would focus on exploring the interaction mechanisms between and the host.
The number of publications on TB vaccines has grown over the past two decades. Developed countries play a significant role in TB vaccine research, and developing countries are fast catching up. We believe that future research will be aimed at understanding the fine molecular mechanisms of host-pathogen interaction, leading to the development of better TB vaccines.
结核病（TB）是一种由感染引起的古老传染病。疫苗接种是预防和控制结核病最有效的方法。然而，从文献计量学角度系统分析新型结核病疫苗研究进展的文献相对较少。本研究旨在考察过去20年结核病疫苗的发展情况，并确定未来的研究重点和方向。
选择Web of Science核心合集（WOSCC）数据库中的科学引文索引扩展版（SCI-E）来检索与结核病疫苗相关的文献。使用VOSviewer、CiteSpace和Bibliometrix软件对每篇出版物的国家、机构、作者、期刊、参考文献和关键词进行分析和可视化。此外，还使用GraphPad Prism和Microsoft Excel 365进行统计分析。
截至2022年10月20日，共识别出7960篇与结核病疫苗相关的出版物，被引次数达288478次。美国占比最大（2658篇，33.40%），其次是英国（1301篇，16.34%）和中国（685篇，8.6%）。在机构方面，伦敦大学的出版物最多（427篇），并与丹麦国家血清研究所共享最高H指数（76）。就期刊和作者的文章数量而言，《疫苗》杂志以629篇文章位居第一。彼得·安德森教授发表的论文数量最多（160篇）。突发关键词和主题地图分析表明，结核病疫苗开发的未来趋势将集中在探索[此处原文缺失相关内容]与宿主之间的相互作用机制。
在过去二十年中，关于结核病疫苗的出版物数量有所增加。发达国家在结核病疫苗研究中发挥着重要作用，发展中国家也在迅速追赶。我们认为，未来的研究将旨在了解宿主-病原体相互作用的精细分子机制，从而开发出更好的结核病疫苗。
