Ghoneim M M, Hinrichs J V, Mewaldt S P
Clin Pharmacol Ther. 1986 May;39(5):491-500. doi: 10.1038/clpt.1986.86.
The effects of diazepam (0.2 mg/kg for 15 days followed by 0.3 mg/kg for 7 days), oxazepam (0.8 mg/kg for 15 days followed by 1.2 mg/kg for 7 days), and placebo were studied in healthy subjects after the first dose, once a week during chronic dosing, and at 48 and 96 hours after withdrawal through a battery of psychologic tests. Diazepam produced quick effects followed by relatively rapid recovery, whereas the effects of oxazepam appeared slowly and lasted longer. Tolerance developed to the effects of both active drugs, so that when the dosages were increased, effects did not. There were no symptoms or signs indicative of withdrawal reactions. There were also no differences between the effects of the two active drugs after repeated dosing, although diazepam is an accumulating drug with active metabolites and oxazepam is a slightly accumulating one with inactive metabolites.
在健康受试者中，通过一系列心理测试研究了地西泮（先0.2毫克/千克，持续15天，后0.3毫克/千克，持续7天）、奥沙西泮（先0.8毫克/千克，持续15天，后1.2毫克/千克，持续7天）和安慰剂在首次给药后、慢性给药期间每周一次以及停药后48小时和96小时的效果。地西泮起效迅速，随后恢复相对较快，而奥沙西泮的效果出现较慢且持续时间更长。两种活性药物的效果均产生了耐受性，因此当剂量增加时，效果并未增强。没有出现表明戒断反应的症状或体征。尽管地西泮是一种具有活性代谢物的蓄积性药物，奥沙西泮是一种具有非活性代谢物的轻度蓄积性药物，但重复给药后两种活性药物的效果之间也没有差异。
