Berkin K E, Inglis G C, Ball S G, Thomson N C
Clin Sci (Lond). 1986 Apr;70(4):347-52. doi: 10.1042/cs0700347.
Airway, cardiovascular and metabolic responses were measured in six asthmatic patients with stable asthma during separate adrenaline, noradrenaline and control infusions. Four incremental infusion rates (4, 10, 25 and 62.5 ng min-1 kg-1) produced circulating catecholamine concentrations within the physiological range. Specific airways conductance and maximal expiratory flow rates measured from complete and partial flow-volume curves increased significantly (P less than 0.05) during adrenaline infusion, in a dose-response manner. No changes in specific airways conductance or maximal expiratory flow rates were seen during the noradrenaline or control infusion. The highest adrenaline infusion rate caused a rise in systolic blood pressure (P less than 0.05) and plasma glucose (P less than 0.05) and a fall in plasma potassium (P less than 0.05). Noradrenaline infusion caused a slight increase in diastolic blood pressure (P less than 0.05) but no metabolic changes. No cardiovascular or metabolic changes occurred during the control infusion. Infused adrenaline, producing circulating concentrations within the physiological range, caused dose-related bronchodilatation in asthmatic patients. Circulating noradrenaline does not appear to have a role in the control of basal airway tone in asthmatic patients.
在六名病情稳定的哮喘患者中，分别在输注肾上腺素、去甲肾上腺素及进行对照输注期间，对气道、心血管及代谢反应进行了测量。四种递增输注速率（4、10、25及62.5纳克·分钟⁻¹·千克⁻¹）使循环儿茶酚胺浓度处于生理范围内。在输注肾上腺素期间，根据完整和部分流量-容积曲线测得的比气道传导率和最大呼气流量以剂量反应方式显著增加（P<0.05）。在输注去甲肾上腺素或进行对照输注期间，未观察到比气道传导率或最大呼气流量有变化。最高肾上腺素输注速率导致收缩压升高（P<0.05）、血糖升高（P<0.05）以及血钾降低（P<0.05）。输注去甲肾上腺素导致舒张压略有升高（P<0.05），但未引起代谢变化。在对照输注期间未出现心血管或代谢变化。输注处于生理范围内浓度的肾上腺素可使哮喘患者出现剂量相关的支气管扩张。循环中的去甲肾上腺素似乎在哮喘患者基础气道张力的控制中不起作用。
