Berkin K E, Inglis G C, Ball S G, Thomson N C
Q J Exp Physiol. 1985 Apr;70(2):203-9. doi: 10.1113/expphysiol.1985.sp002903.
Airway, cardiovascular and metabolic responses were measured in six normal subjects during separate infusions of adrenaline and noradrenaline. Four incremental infusion rates of the catecholamines (4, 10, 25 and 62.5 ng X kg-1 X min-1) produced circulating levels of adrenaline and noradrenaline within the physiological range. Maximal expiratory flow rates at 25% of vital capacity measured from partial flow-volume curves increased sequentially with increasing adrenaline concentration. Increases in maximal expiratory flow rates at 25% and 50% of vital capacity measured from complete flow-volume curves were not statistically significant, nor were the changes in specific conductance. Small but insignificant changes were observed in heart rate and blood pressure during adrenaline infusion. Plasma glucose increased and serum potassium fell during adrenaline infusion. No significant airway, cardiovascular or metabolic responses were seen during noradrenaline infusion. These results suggest that adrenaline, at concentrations found in physiological circumstances, influences flow rates in small airways. Circulating noradrenaline does not appear to be important in the control of airway calibre in normal subjects.
在六名正常受试者分别输注肾上腺素和去甲肾上腺素期间，对气道、心血管和代谢反应进行了测量。儿茶酚胺的四种递增输注速率（4、10、25和62.5 ng·kg⁻¹·min⁻¹）使肾上腺素和去甲肾上腺素的循环水平处于生理范围内。根据部分流量-容积曲线测量的肺活量25%时的最大呼气流量率随肾上腺素浓度升高而依次增加。根据完整流量-容积曲线测量的肺活量25%和50%时的最大呼气流量率增加无统计学意义，比导率变化也无统计学意义。肾上腺素输注期间，心率和血压出现微小但无显著意义的变化。肾上腺素输注期间血浆葡萄糖升高，血清钾降低。去甲肾上腺素输注期间未观察到明显的气道、心血管或代谢反应。这些结果表明，在生理情况下发现的浓度的肾上腺素会影响小气道的流速。循环中的去甲肾上腺素在正常受试者气道口径的控制中似乎并不重要。
