离子有机固体 1,3-双（磺甲基）咪唑𬭩盐作为一种有效的无金属催化剂用于可持续的有机合成。

Organic Chemistry Department and Institute of Organic Synthesis (ISO), University of Alicante, ctra. San Vicente del Raspeig s/n, 03690 Alicante, San Vicente del Raspeig, Spain.

Molecules. 2023 Mar 16;28(6):2695. doi: 10.3390/molecules28062695.

The 1,3-bis(sulfomethyl)imidazole (bsmim) was effectively prepared by a multicomponent reaction, employing aminomethanesulfonic acid, glyoxal, and formaldehyde. The catalytic activity of bsmim was tested in the synthesis of quinoline derivatives, by means of the Friedländer reaction, and in the allylic substitution of alcohols with nitrogen-containing heterocycles. The performance of sulfo-imidazole derivative (bsmim) resulted in higher comparison with the carboxyimidazole analogs (bcmim and bcmimCl), under the same reaction conditions. This type of ionic organic solid allows the promotion of reactions in the absence of solvent and mild reaction conditions, which improves the sustainability of organic synthetic processes.

1,3-双(磺甲基)咪唑（bsmim）通过多组分反应，使用甲亚磺酸钠、乙二醛和甲醛有效制备。bsmim 的催化活性通过 Friedländer 反应在喹啉衍生物的合成以及含氮杂环的醇的烯丙基取代中进行了测试。在相同的反应条件下，磺酰咪唑衍生物（bsmim）的性能与羧酸咪唑类似物（bcmim 和 bcmimCl）相比，表现出更高的催化活性。这种类型的离子有机固体允许在没有溶剂和温和反应条件下促进反应，从而提高有机合成过程的可持续性。