白术炭衍生碳点的止血和保肝生物活性。
Hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots.
机构信息
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
出版信息
Nanomedicine (Lond). 2019 Feb;14(4):431-446. doi: 10.2217/nnm-2018-0285. Epub 2019 Jan 30.
AIM
To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs).
MATERIALS & METHODS: The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom.
RESULTS
The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin.
CONCLUSION
The JMC-CDs may have great potentials in clinical practice.
目的
探索白术炭衍生碳点（JMC-CDs）的止血和保肝生物活性。
材料与方法
采用透射电子显微镜、高效液相色谱、傅里叶变换红外、紫外、荧光和 X 射线光电子能谱对 JMC-CDs 进行了表征。通过创伤性出血动物模型和尖吻蝮蛇毒诱导的内出血动物模型评价和证实了 JMC-CDs 的止血作用。
结果
JMC-CDs 的直径为 1.0 至 8nm，产率为 0.12%。此外，JMC-CDs 不仅具有显著的止血功效，还可以预防出血引起的肝损伤，这表现在血清中肝损伤的生化指标（如天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶、总胆红素和直接胆红素）水平降低。
结论
JMC-CDs 在临床实践中可能具有巨大的潜力。
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