Hourfane Sohaib, Mechqoq Hicham, Bekkali Abdellah Yassine, Rocha João Miguel, El Aouad Noureddine
Research Team on Natural Products Chemistry and Smart Technology (NPC-ST), Polydisciplinary Faculty of Larache, Route de Rabat, Abdelmalek Essaadi University, Tetouan 92000, Morocco.
LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.
Plants (Basel). 2023 Mar 9;12(6):1245. doi: 10.3390/plants12061245.
For more than a century, was considered a narcotic and has been banned by lawmakers all over the world. In recent years, interest in this plant has increased due to its therapeutic potential, in addition to a very interesting chemical composition, characterized by the presence of an atypical family of molecules known as phytocannabinoids. With this emerging interest, it is very important to take stock of what research has been conducted so far on the chemistry and biology of . The aim of this review is to describe the traditional uses, chemical composition and biological activities of different parts of this plant, as well as the molecular docking studies. Information was collected from electronic databases, namely SciFinder, ScienceDirect, PubMed and Web of Science. is mainly popular for its recreational use, but it is also traditionally used as remedy for the treatment of several diseases, including diabetes, digestive, circulatory, genital, nervous, urinary, skin and respiratory diseases. These biological proprieties are mainly due to the presence of bioactive metabolites represented by more than 550 different molecules. Molecular docking simulations proved the presence of affinities between compounds and several enzymes responsible for anti-inflammatory, antidiabetic, antiepileptic and anticancer activities. Several biological activities have been evaluated on the metabolites of , and these works have shown the presence of antioxidant, antibacterial, anticoagulant, antifungal, anti-aflatoxigenic, insecticidal, anti-inflammatory, anticancer, neuroprotective and dermocosmetic activities. This paper presents the up-to-date reported investigations and opens many reflections and further research perspectives.
一个多世纪以来，[该植物名称未给出]被视为一种麻醉品，并被世界各国立法者禁止。近年来，由于其治疗潜力，以及非常有趣的化学成分，这种植物受到了更多关注。其化学成分的特点是存在一类非典型分子家族，即植物大麻素。随着这种新出现的关注，对迄今为止在[该植物名称未给出]的化学和生物学方面所做的研究进行总结非常重要。这篇综述的目的是描述这种植物不同部位的传统用途、化学成分和生物活性，以及分子对接研究。信息是从电子数据库收集的，即SciFinder、ScienceDirect、PubMed和Web of Science。[该植物名称未给出]主要因其娱乐用途而广为人知，但传统上也被用作治疗多种疾病的药物，包括糖尿病、消化系统、循环系统、生殖系统、神经系统、泌尿系统、皮肤和呼吸系统疾病。这些生物学特性主要归因于550多种不同分子所代表的生物活性代谢物的存在。分子对接模拟证明了[该植物名称未给出]化合物与几种负责抗炎、抗糖尿病、抗癫痫和抗癌活性的酶之间存在亲和力。已经对[该植物名称未给出]的代谢物进行了几种生物学活性评估，这些研究表明其具有抗氧化、抗菌、抗凝、抗真菌、抗黄曲霉毒素、杀虫、抗炎、抗癌、神经保护和皮肤美容活性。本文介绍了最新报道的研究，并引发了许多思考和进一步的研究方向。
