Lowdell C P, Shousha S, Parkins R A
Dis Colon Rectum. 1986 May;29(5):351-4. doi: 10.1007/BF02554129.
Three cases of secondary amyloidosis are reported, two in patients who had unequivocal Crohn's disease and one in whom the clinical course was that of Crohn's disease, but with histologic findings that were more suggestive of ulcerative colitis. All had evidence of renal failure. A prospective study of 177 patients with inflammatory bowel disease of greater than five years' duration was carried out in an attempt to establish the incidence of secondary amyloidosis, using rectal biopsy and simple renal function tests. No new cases were found. Neither was there evidence of renal failure due to other conditions. In the absence of renal dysfunction, a search for secondary amyloidosis probably is not justified.
报告了3例继发性淀粉样变性病例，其中2例患者患有明确的克罗恩病，1例患者临床病程符合克罗恩病，但组织学检查结果更提示为溃疡性结肠炎。所有患者均有肾衰竭证据。对177例病程超过5年的炎症性肠病患者进行了一项前瞻性研究，试图通过直肠活检和简单的肾功能检查来确定继发性淀粉样变性的发病率。未发现新病例。也没有其他原因导致肾衰竭的证据。在没有肾功能障碍的情况下，寻找继发性淀粉样变性可能没有必要。
