Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir University, Monastir, Tunisia.
Higher Institute of Biotechnology of Monastir, Monastir University, Monastir, Tunisia.
J Biochem Mol Toxicol. 2023 Jun;37(6):e23341. doi: 10.1002/jbt.23341. Epub 2023 Mar 29.
Pesticides have been used to kill pests such as insects, fungi, rodents, and unwanted plants. As these compounds are potentially toxic to the target organisms, they could also be harmful to human health and the environment. Several chronic adverse effects have been identified even after months or years of exposure. The adverse effects of pesticides on the agricultural ecosystem have been a matter of concern in recent decades. In this review, we present an overview of the studies, including our previous studies, monitoring currently used pesticides in the Tunisian agricultural soils that belong to the class of insect growth regulators (IGRs). Triflumuron (TFM) is a benzoyl phenyl urea insecticide belonging to the class of IGRs. TFM is widely used around the world to increase crop yield by protecting them from damage caused by insects. TFM works by inhibiting the synthesis of chitin, an essential part of the insect cuticle, making it susceptible to pathogens and deformities. Consequently, insects become more susceptible to pathogens and malformations. However, studies revealing its toxicity and its mode of action in mammalian systems remain very limited. The aim of this review is to better inform the community about the impact of TFM on crops, the environment, and human beings by summarizing its toxic effects.
农药被用于杀死害虫，如昆虫、真菌、啮齿动物和不需要的植物。由于这些化合物对目标生物可能有毒，它们也可能对人类健康和环境造成危害。即使在暴露数月或数年后，也已经确定了几种慢性不良反应。几十年来，农药对农业生态系统的不良影响一直是人们关注的问题。在这篇综述中，我们概述了研究情况，包括我们以前的研究，监测属于昆虫生长调节剂 (IGR) 类别的目前在突尼斯农业土壤中使用的农药。噻虫嗪 (TFM) 是一种苯甲酰基苯脲杀虫剂，属于 IGR 类。TFM 被广泛用于世界各地，通过保护作物免受昆虫造成的损害来提高作物产量。TFM 通过抑制几丁质的合成起作用，几丁质是昆虫外骨骼的重要组成部分，使其易受病原体和畸形的影响。因此，昆虫更容易受到病原体和畸形的影响。然而，关于其在哺乳动物系统中的毒性及其作用模式的研究仍然非常有限。本综述的目的是通过总结其毒性作用，让更多人了解 TFM 对作物、环境和人类的影响。
