Nurs Res. 2023;72(4):326-333. doi: 10.1097/NNR.0000000000000657. Epub 2023 Apr 5.
Acute ischemic stroke is one of the leading causes of death and disability globally. Recent advances in omics methodology enable lipidomic profiling, which may provide knowledge of the underlying pathology of acute ischemic stroke and its associated outcomes.
This study aims to examine the longer-term relationships between symptoms and outcomes following acute ischemic stroke and the underlying lipidomic signatures over 6 months during recovery between acute ischemic stroke patients who received reperfusion therapies and those who did not.
This prospective cohort study will enroll 104 participants post-acute ischemic stroke in two groups based on their receipt of reperfusion therapy (Group 1) or not (Group 2; n = 52/group). Peripheral plasma samples will be collected from both groups for lipidomic analysis over 6 months. Arterial blood samples will be collected during the procedure for those receiving reperfusion. Self-reported symptoms and outcome data will be collected from both groups.
We will compare and examine the associations among plasma lipidomic biomarkers and symptoms and cognitive, functional, and health-related quality of life outcomes over 6 months between acute ischemic stroke patients who did and did not receive reperfusion intervention.
急性缺血性脑卒中是全球范围内导致死亡和残疾的主要原因之一。组学方法的最新进展使脂质组学分析成为可能，这可能为急性缺血性脑卒中的潜在病理及其相关结局提供相关知识。
本研究旨在探讨接受再灌注治疗和未接受再灌注治疗的急性缺血性脑卒中患者在急性发病后 6 个月的恢复期内，症状与结局之间以及潜在脂质组学特征之间的长期关系。
这项前瞻性队列研究将根据接受再灌注治疗（1 组）或未接受再灌注治疗（2 组；每组 n = 52）将 104 名急性缺血性脑卒中患者分为两组。两组患者在 6 个月内将采集外周血浆样本进行脂质组学分析。对于接受再灌注的患者，将在手术期间采集动脉血样。将从两组患者中收集自述症状和结局数据。
我们将比较和检查在接受和未接受再灌注干预的急性缺血性脑卒中患者中，6 个月内血浆脂质组学生物标志物与症状以及认知、功能和健康相关生活质量结局之间的关联。
