[组织纤溶酶原激活剂增强牛3型腺病毒对培养小鼠细胞的诱变和转化作用]
[TPA enhancement of the mutagenic and transforming action of bovine adenovirus type 3 on cultured mouse cells].
作者信息
Lukash L L, Kononenko L I, Buzhievskaia T I, Bykorez A I, Shapiro N I
出版信息
Eksp Onkol. 1985;7(1):30-2.
PMID:3979337
Abstract
The cultured 10TI/2C3H mouse cells were infected with bovine adenovirus 3(BAV-3) and treated by TPA. This combined treatment induced ouabain-resistant mutants 19 to 26 times more often than action of only BAV-3. BAV-3- and TPA-treated cells were implanted to syngenic mice. The tumours appeared 10 times more often than in the mice after implantation of only adenovirus treated cells.
摘要
将培养的10TI/2C3H小鼠细胞用牛腺病毒3（BAV-3）感染并经佛波酯（TPA）处理。这种联合处理诱导哇巴因抗性突变体的频率比仅用BAV-3处理高19至26倍。将经BAV-3和TPA处理的细胞植入同基因小鼠体内。肿瘤出现的频率比仅植入经腺病毒处理细胞的小鼠高10倍。
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