[TPA enhancement of the mutagenic and transforming action of bovine adenovirus type 3 on cultured mouse cells].

The cultured 10TI/2C3H mouse cells were infected with bovine adenovirus 3(BAV-3) and treated by TPA. This combined treatment induced ouabain-resistant mutants 19 to 26 times more often than action of only BAV-3. BAV-3- and TPA-treated cells were implanted to syngenic mice. The tumours appeared 10 times more often than in the mice after implantation of only adenovirus treated cells.