Pei Y Q, Koyama I
Epilepsia. 1986 May-Jun;27(3):183-8. doi: 10.1111/j.1528-1157.1986.tb03526.x.
Seizure produced by intrahippocampal injection of zinc sulfate in rabbits is a new chronic model of experimental epilepsy. In this model, the clinical manifestations are easily observed and are expressed not only as partial clonic seizures, but also by secondary generalized seizures. The electrohippocampalogram (EHG) and electrocorticogram (ECoG) discharges change correspondingly during both types of seizures, and last for weeks. The mechanism for induced seizures may be partly related to the inhibitory effect of zinc sulfate injections on the acetylcholinesterase (AchE) activity in the hippocampus. The commonly used antiepileptic drugs, such as phenobarbital and phenytoin, afforded protection against the zinc-induced secondary generalized clonic seizures and alleviated the partial clonic seizures but had no influence on the EHG- and ECoG-monitored periodic bursts of spike discharges. Nitrazepam was found to antagonize both types of seizures and also transiently restored the EHG and ECoG to normal. D-penicillamine, a metal chelator, may be the most effective agent for the treatment of zinc-induced seizures; the agent, in addition to affording protection against both types of seizures, also caused the periodic burst spike discharges in EHG and ECoG to disappear.
通过向兔海马内注射硫酸锌诱导的癫痫发作是一种新型的实验性慢性癫痫模型。在该模型中，临床表现易于观察，不仅表现为部分阵挛性发作，还会出现继发性全身性发作。在这两种类型的发作过程中，海马电图（EHG）和皮质电图（ECoG）放电相应改变，并持续数周。诱导癫痫发作的机制可能部分与硫酸锌注射对海马中乙酰胆碱酯酶（AchE）活性的抑制作用有关。常用的抗癫痫药物，如苯巴比妥和苯妥英钠，可预防锌诱导的继发性全身性阵挛性发作，并减轻部分阵挛性发作，但对EHG和ECoG监测到的周期性棘波放电无影响。发现硝西泮可对抗这两种类型的发作，并能使EHG和ECoG短暂恢复正常。金属螯合剂D-青霉胺可能是治疗锌诱导癫痫发作最有效的药物；该药物除了预防这两种类型的发作外，还能使EHG和ECoG中的周期性棘波放电消失。
