Pei Y, Zhao D, Huang J, Cao L
Epilepsia. 1983 Apr;24(2):169-76. doi: 10.1111/j.1528-1157.1983.tb04876.x.
Seizures produced by intracerebral injection of zinc sulfate in rabbits are a new chronic model of experimental epilepsy. The main features of this model are: the animals are easily controlled, the electrocorticogram is conveniently recorded, the endpoints are definite, and the rate of seizure is higher than with other methods. The commonly used antiepileptic drugs, such as phenobarbital (30 mg/kg), diphenylhydantoin (30 mg/kg), nitrazepam (3 mg/kg), and sodium valproate (300 mg/kg), have therapeutic effects in treating this experimental epilepsy, when they are given intravenously. But they can not protect the rabbits from death, except phenobarbital.
通过向家兔脑内注射硫酸锌诱导的癫痫发作是一种新型的慢性实验性癫痫模型。该模型的主要特点是：动物易于控制，皮层脑电图便于记录，终点明确，癫痫发作率高于其他方法。常用的抗癫痫药物，如苯巴比妥（30mg/kg）、苯妥英钠（30mg/kg）、硝西泮（3mg/kg）和丙戊酸钠（300mg/kg），静脉给药时对治疗这种实验性癫痫有治疗作用。但除苯巴比妥外，它们不能保护家兔免于死亡。
