血清 Bhlhe40 水平与 2 型糖尿病患者亚临床动脉粥样硬化相关：一项横断面研究。
High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study.
机构信息
Department of Geriatrics, 619959The Second Xiangya Hospital of Central South University, Changsha, China.
Institute of Aging and Age-related Disease Research, Central South University, Changsha, China.
出版信息
Diab Vasc Dis Res. 2023 Mar-Apr;20(2):14791641231169246. doi: 10.1177/14791641231169246.
BACKGROUND
Our previous studies have shown that the basic helix-loop-helix family member e40 (Bhlhe40) plays a critical role in regulating calcification and senescence of vascular smooth muscle cells induced by high glucose. In this study, we determined the association between serum Bhlhe40 levels and subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM).
METHODS
247 patients with T2DM were included in this cross-sectional study between June 2021 and July 2022. The presence of subclinical atherosclerosis was evaluated by carotid ultrasonography. Serum Bhlhe40 concentrations were measured with an ELISA kit.
RESULTS
Serum Bhlhe40 levels were remarkably higher in the subclinical atherosclerosis group than in the subjects without subclinical atherosclerosis ( < 0.001). Correlation analysis showed a positive correlation between serum Bhlhe40 and carotid intima-media thickness (C-IMT) ( = 0.155, = 0.015). The optimal threshold of serum Bhlhe40 > 5.67 ng/mL had an area under the ROC curve (AUC) was 0.709 ( < 0.001). In addition, serum Bhlhe40 levels were associated with the prevalence of subclinical atherosclerosis (OR: 1.790, 95% CI: 1.414-2.266, < 0.001).
CONCLUSION
Serum Bhlhe40 levels were significantly higher in T2DM subjects with subclinical atherosclerosis and positively associated with C-IMT.
背景
我们之前的研究表明，碱性螺旋-环-螺旋家族成员 e40（Bhlhe40）在调节高糖诱导的血管平滑肌细胞钙化和衰老中起关键作用。在这项研究中，我们确定了血清 Bhlhe40 水平与 2 型糖尿病患者亚临床动脉粥样硬化之间的关系。
方法
本横断面研究于 2021 年 6 月至 2022 年 7 月纳入 247 例 2 型糖尿病患者。通过颈动脉超声评估亚临床动脉粥样硬化的存在。使用 ELISA 试剂盒测量血清 Bhlhe40 浓度。
结果
亚临床动脉粥样硬化组血清 Bhlhe40 水平明显高于无亚临床动脉粥样硬化组（ < 0.001）。相关性分析显示，血清 Bhlhe40 与颈动脉内膜-中层厚度（C-IMT）呈正相关（ = 0.155， = 0.015）。血清 Bhlhe40 > 5.67 ng/mL 的最佳截断值的 ROC 曲线下面积（AUC）为 0.709（ < 0.001）。此外，血清 Bhlhe40 水平与亚临床动脉粥样硬化的患病率相关（OR：1.790，95%CI：1.414-2.266， < 0.001）。
结论
血清 Bhlhe40 水平在伴有亚临床动脉粥样硬化的 2 型糖尿病患者中明显升高，并与 C-IMT 呈正相关。
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